Fri.Jul 26, 2024

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Opinion: Without federal oversight, nursing homes will put profit ahead of care

STAT

About 5% of Americans require skilled care at some point as they age. The horrific reports of more than 200,000 deaths of nursing home residents and staff during the Covid-19 pandemic put the nursing home industry under intense national scrutiny. But not all nursing homes experienced this level of tragedy and loss. One major reason why some fared better than others was adequate nurse staffing.

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Drugflation Is Soaring, But It Can Be Tamed

Pharmacy Times

Unbridled drugflation, or a point-in-time measure of the rising cost of pharmacy benefits, is taking its toll on corporate bottom lines and household budgets.

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STAT+: How Pfizer’s grand gene therapy ambitions crumbled

STAT

A decade ago, Pfizer began investing heavily in gene therapy, bringing in experimental treatments for a range of genetic diseases, pumping $800 million into “state-of-the-art” manufacturing facilities and announcing its intention to become an “industry leader” that would deliver “one-time, transformative therapies” for rare diseases.

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JNJ-2056, Targeting Tau Protein, Receives FDA Fast Track Designation for Alzheimer Disease

Pharmacy Times

The FDA’s designation builds off positive results in a phase 1b/2a clinical trial, showing that the vaccine can effectively target the Tau protein.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Morning Rounds: Three new bird flu cases in humans brings total to 13 in U.S.

STAT

Want to stay on top of health news? Sign up to get our Morning Rounds newsletter in your inbox. I’m Brittany Trang, STAT health tech reporter and your new Friday morning host.

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Prenatal Cannabis Use and Maternal Health Outcomes

Drug Topics

Researchers aimed to address the associations between prenatal cannabis use and maternal health outcomes over a 9-year period.

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More Trending

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Persistent Epigenetic Changes in Immune Cells Following Hepatitis C Recovery

Pharmacy Times

Study finds traces of “epigenetic scars” on the immune cells of patients who recovered from chronic hepatitis C infection.

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STAT+: European regulators say Alzheimer’s therapy Leqembi should be rejected

STAT

LONDON — European regulators on Friday said that an Alzheimer’s therapy from Eisai and Biogen should be rejected, again diverging from their U.S. counterparts on a medicine for a condition where treatments are desperately needed. In a statement, the regulators said that the benefits of Leqembi did not outweigh the risks of potentially dangerous side effects.

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Personalized Simulations Can Predict Outcomes for Treatment in Patients With Diffuse Large B-Cell Lymphoma

Pharmacy Times

The new approach could optimize precision medicine and lead to better outcomes across a variety of disease states.

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What happens if I suddenly stop taking Trintellix?

The Checkup by Singlecare

The World Health Organization once predicted depression would be the leading cause of disease burden by 2030. Fortunately, antidepressants like Trintellix (vortioxetine) can help carry the weight of that burden. Like many drugs that treat major depressive disorder, Trintellix influences the brain’s serotonin levels to help regulate moods—but stopping treatment can get complicated.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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STAT+: Pharmalittle: We’re reading about a thumbs down for an Alzheimer’s drug, Pfizer gene therapy struggles, and more

STAT

And so, another working week will soon draw to a close. Not a moment too soon, yes? This is, you may recall, our treasured signal to daydream about weekend plans. Our agenda is fairly modest. We hope to catch up on our reading, spend time with our Pharmalot ancestor, and promenade with the official mascots. We also hope to hold another listening party, where the rotation will likely feature this , this , this , and this.

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Giroctocogene Fitelparvovec Reduces Total Annualized Bleeding Rate for Hemophilia A

Pharmacy Times

The investigational drug achieved non-inferiority compared to routine Factor VIII.

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AZ joins call for new UK PM to back Oxford-Cambridge hub

pharmaphorum

Leading figures from industry and academia, including AstraZeneca, have urged UK PM Keir Starmer to turn the Oxford-Cambridge region into the "crown jewel" of his industrial growth plan

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Blood Test May Predict CAR T-Cell Therapy Outcomes for Patients With Multiple Myeloma

Pharmacy Times

Increased levels of absolute lymphocyte count are associated with improved response to BCMA-targeted CAR T-cell therapy.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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In shock move, EU panel rejects Alzheimer's drug Leqembi

pharmaphorum

CHMP recommends against approval of Eisai, Biogen's Alzheimer's disease therapy Leqembi, saying side effects outweigh its benefits

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How Cure51’s AI breakthroughs are turning cancer into a manageable disease – an insider’s look

Outsourcing Pharma

Discover the groundbreaking work of Cure51, co-founded by Nicolas Wolikow and Simon Istolainen, revolutionizing cancer treatment through advanced AI and biotechnology.

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The worst for Dexcom may not be over

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Good morning. We’ve made it to the end of the week! I don’t know about you, but it’s felt like an especially long week for me. It’s probably cause of all the news that we will get into right now.

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FDA Roundup: Agency Highlights from July 2024

Drug Topics

Check out these important FDA updates from the month of July 2024.

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RSV Vaccination: Building Trust in Communities

Pharmacy Times

Understanding preventive care reduces the risk of illnesses and decreases future costs.

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Opinion: Medtech compliance — not regulation — is stifling innovation

STAT

“Regulation is stifling innovation” seems to be a prevailing opinion among medtech leaders who believe the Food and Drug Administration’s rules are slowing medical device advancements — especially when it comes to software. I couldn’t disagree more. As someone who has led artificial intelligence (AI) and machine learning (ML) efforts at Amgen, I’ve seen firsthand how vital these regulations are for keeping patients safe.

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J&J's Texas two-step bankruptcy maneuver shut down again by appeals court

Fierce Pharma

Johnson & Johnson’s latest attempt to get a handle on its talc litigation using the controversial Texas two-step bankruptcy strategy has once again fallen flat after a federal appeals court rul | The ruling from the Third Circuit Court of Appeals came the night before claimants in the talc litigation were set to vote on a sweeping $6.48 billion settlement proposal from J&J.

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Health Innovators - Steve Damon

pharmaphorum

Discover the innovative work of Steven Damon, the CEO of Micron Biomedical, a company specialising in microneedle technology for improved healthcare delivery. Learn about his cutting-edge innovations in the field.

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Bristol Myers CEO 'increasingly confident' company can handle IRA pricing on Eliquis

Fierce Pharma

Amid the sturm und drang over Inflation Reduction Act (IRA) drug price negotiations, Bristol Myers Squibb has been among the biopharma companies casting the most woe over the oncoming measures. | Bristol Myers Squibb CEO Chris Boerner said after seeing the final negotiated price for Eliquis that he is "increasingly confident" the company can navigate the impact of the IRA.

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5 strategies for biopharma to optimise patient recruitment in clinical trials

pharmaphorum

Discover 5 effective strategies for biopharma companies to optimize patient recruitment in clinical trials. Learn how to enhance recruitment processes and increase patient participation.

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Chasing Pfizer and Lilly, Sun Pharma wins FDA nod for alopecia areata med Leqselvi

Fierce Pharma

After Eli Lilly’s Olumiant won the distinction of becoming the first med approved by the FDA to treat the follicle-attacking autoimmune disease alopecia areata, Pfizer followed up with a green ligh | The FDA signed off on Sun’s oral JAK inhibitor deuruxolitinib to treat adults with severe alopecia areata. The drug is now approved in 8 mg tablets under the brand name Leqselvi.

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Creative review: The Cannes Lions trends that pharma needs to know about

pharmaphorum

Discover the top 7 trends from the Cannes Lions Festival that pharma professionals should be aware of. Stay ahead of the game with these creative insights.

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STAT+: Up and down the ladder: The latest comings and goings

STAT

Hired someone new and exciting? Promoted a rising star? Finally solved that hard-to-fill spot? Share the news with us, and we’ll share it with others.  That’s right. Send us your changes, and we’ll find a home for them. Don’t be shy. Everyone wants to know who is coming and going. And here is our regular feature in which we highlight a different person each week.

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6 benefits of betaine

The Checkup by Singlecare

Betaine is an amino acid that your body naturally produces. It’s found in some common foods, like beets, spinach, shellfish, and whole grains, such as wheat bran and wheat germ. Betaine helps to stabilize proteins, enzymes, and cells, protecting them from stress associated with fluid shifts. Another of the main benefits of betaine is helping your body eliminate a toxic amino acid called homocysteine.

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Revolutionary Alzheimer's drug donanemab approved – what does this mean for the future of care?

Outsourcing Pharma

The approval of donanemab marks a significant breakthrough in Alzheimer's treatment, promising transformative changes in patient care and research.

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Indole-3-Propionic Acid Shows Long-Term Protection Against Asthma

Pharmacy Times

The molecule can be a potential treatment that counters effects of early-life antibiotics, which can impact the gut microbiota and increase the risk of childhood atopy and asthma.

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Citius’ first FDA decision date is approaching — and its CEO has millions on the line

PharmaVoice

Citius Pharmaceuticals CEO Leonard Mazur has personally invested $22.5 million into the company, which is fast approaching a potential turning point.

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Manifestation of Pneumococcal Disease in Adults

Pharmacy Times

Medical professionals describe how pneumococcal disease manifests in adults, detailing its potentially lethal consequences such as sepsis or severe pneumonia, and explain how vaccination can effectively mitigate these serious health risks.

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GSK blows Jemperli marching brass against Keytruda with expanded FDA nod in endometrial cancer

Fierce Pharma

Merely a month into an FDA approval for a broad first-line endometrial cancer population, Merck’s Keytruda has some company. | Merely a month into an FDA approval for a broad first-line endometrial cancer population, Merck’s Keytruda has some company in the form of a matching go-ahead by GSK's Jemperli.

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Centene posts $1.1B in Q2 profit as it faces down Medicaid headwinds

Fierce Healthcare

Centene beat the Street even as Medicaid redeterminations pose a significant headwind heading into the back half of 2024, according to its

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