Fri.Mar 29, 2024

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Ozempic, Other GLP-1 Therapies Caused Major Increase in Medicare Spending

Drug Topics

After semaglutide and tirzepatide were approved, and ozempic use continues to rise, Medicare spending is also increasing because of a high demand for GLP-1 therapies.

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Why researchers think human milk could repair the gut microbiome and reduce infections

STAT

For babies who are breastfed, their first source of sustenance is filled with proteins, sugars, hormones, vitamins, and minerals — just the right amount of nutrients for an infant. That milk could also lower the risk of asthma , diabetes, and allergies. And it could make low-birth-weight, preterm babies up to 10 times less likely to develop necrotizing enterocolitis , a common intestinal disorder.

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Demographics Significantly Influence Common Customer Behavior at Community Pharmacies

Drug Topics

Researchers found various reasons for why individuals chose a specific pharmacy and how they purchase OTC medication.

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'Things get built and forgotten about': The challenging work of maintaining AI tools in clinical settings

Fierce Healthcare

With AI being all the buzz in healthcare today, many questions about the technology still remain. Do clinicians understand and trust AI tools? Are algorithms accurate and free from bias? | At the 2024 SXSW conference, a panel on the future of AI in healthcare moderated by AMA President Jesse Ehrenfeld, M.D., discussed what's still needed for safer, more integrated and more impactful systems.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Drug Companies to Pay Medicare Rebates if Prices Rise Faster Than Inflation

Drug Topics

Thanks to the Inflation Reduction Act, Medicare Part B coinsurance rates will lower if drug prices rise faster than the rate of inflation.

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GLP-1 generics would be dramatically cheaper than U.S. price of Ozempic, study shows, but still profitable

STAT

Diabetes drugs are too expensive in the U.S., and insulin is infamously six to 13 times more expensive here than in comparable high-income countries. And blockbuster GLP-1 drugs, too, could be a lot less expensive, according to an investigation published this week in JAMA Network Open, with a simple change: robust generic competition. The study, led by Melissa Barber, a Yale postdoctoral fellow, and conducted in collaboration with Doctors Without Borders, a nonprofit medical organization working

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Bristol Myers Squibb's versatile Zeposia doesn't make the grade in Crohn's disease trial

Fierce Pharma

Bristol Myers Squibb’s Zeposia (ozanimod) has attracted attention as a treatment for an unusual duo of diseases—multiple sclerosis (MS) and ulcerative colitis (UC). | Bristol Myers Squibb’s Zeposia has attracted attention as a treatment for an odd pair of unrelated diseases—multiple sclerosis (MS) and ulcerative colitis (UC). But the approval roll for the sphingosine 1-phosphate (S1P) receptor modulator may be over.

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Study Finds ALL Genetic Variant That Indicates Why Hispanic, Pediatric Patients Are Likely to Develop Disease

Pharmacy Times

Pediatric patients with the variant were approximately 1.44 times more likely develop ALL compared with children who do not have the variant.

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After Amgen's stumble, BMS touts KRAS confirmatory trial win for newly bought Krazati

Fierce Pharma

Bristol Myers Squibb looks on track to overtake Amgen as the KRAS leader in lung cancer after following up its rival’s FDA setback with a positive confirmatory trial readout. | Bristol Myers Squibb looks on track to overtake Amgen as the KRAS leader in lung cancer after following up its rival’s FDA setback with a positive confirmatory trial readout.

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Industry Voices—Pregnant Medicaid beneficiaries need better access to prenatal vaccines. Simple state reforms can help

Fierce Healthcare

As public health officials nationwide sound the alarm on a “tripledemic”—the emergence of the respiratory syncytial virus (RSV), the influenza virus and the COVID-19 virus simultaneously—pregnant w | Given that Medicaid and CHIP cover a significant portion of all pregnancies in America—especially for historically disadvantaged groups—policy actions could play a key role in supporting vaccine access and health equity.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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The Rising Tide of Biopharma Manufacturing Costs

Pharmaceutical Commerce

In this Pharmaceutical Commerce video interview, Barry Heavey, Life Sciences Supply Chain Lead, Accenture, discusses the specific factors contributing to rising manufacturing costs.

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Report claims WuXi shared US client IP with China

pharmaphorum

Report claims US intelligence services advised the authors of the BIOSECURE Act that WuXi AppTec shared confidential data on US clients with the Chinese government

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The unrecognized threat of PAD

Fierce Pharma

This week on “The Top Line,” we explore peripheral arterial disease, a serious health issue that is often overlooked and undermanaged. | This week on “The Top Line,” join Editor-in-Chief of Fierce Life Sciences and Healthcare Ayla Ellison as she sits down with Kumar Madassery, M.D., Director of Peripheral Vascular Intervention & CLI Program at Rush University Medical Center, to explore peripheral arterial disease—a serious health issue that is often overlooked and undermanaged.

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Researchers Identify Two Mutations Potentially Linked to Rare Blood Disorder

Pharmacy Times

The mutations, C594Y and P735R, were found in the GNE gene and may influence sialylation, a process that is crucial for brain development.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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'Unprecedented' demand for Eli Lilly's Zepbound sparks US supply constraints

Fierce Pharma

Once again, a medicine in the popular GLP-1 class of diabetes and weight loss therapies is facing supply hurdles. | While the drug is not listed on the FDA's shortage list, some pharmacies are facing supply issues. Amazon Pharmacy, for instance, notes that several dosage strengths are "unavailable.

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FDA Grants ODD to AP303 for Treatment of Patients With Autosomal Dominant Polycystic Kidney Disease

Pharmacy Times

The ODD comes after AP303 presented meaningful improvements in renal survival in an ADPKD and the completion of the first study that evaluated healthy human participants.

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Disappointment for BMS as Zeposia fails Crohn’s study

pharmaphorum

Bristol-Myers Squibb's Zeposia has failed to outperform placebo in its first phase 3 test in Crohn's disease

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What’s Congress going to do with WuXi?

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Hello, everyone. Damian here with a look at key Supreme Court decision, the latest biotech IPO, and intrigue over Chinese outsourcing.

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Direct Oral Anticoagulant Use for Left Ventricular Thrombus Treatment

Pharmacy Times

An overview of the use of direct oral anticoagulants as an alternative to warfarin in the treatment of left ventricular thrombus.

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STAT+: Pharmalittle: We’re reading about Wegovy insurance coverage, Zepbound shortages, and more

STAT

And so, another working week will soon draw to a close. Not a moment too soon, yes? This is, you may recall, our treasured signal to daydream about weekend plans. Our agenda is still being formulated, but we do hope to promenade with the official mascots, catch up on our reading, and maybe stare at the telly now and then. Of course, we are also planning another listening party, where the rotation will include this , this , this and this.

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Exposure to Residential Greenness During Pregnancy Associated With Increased Risk of Asthma

Pharmacy Times

The effects were strongest during the spring season and in the third trimester of pregnancy.

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Teva, following Hikma complaint, alleges Amarin 'locked up' Vascepa ingredient to block generics

Fierce Pharma

A little more than a year after Hikma Pharmaceuticals accused Amarin of “deliberately and meticulously” hamstringing supplies of the main ingredient in its only marketed drug, Vascepa, to thwart po | A little more than a year after Hikma Pharmaceuticals accused Amarin of “deliberately and meticulously” hamstringing supplies of the main ingredient in its only marketed drug, Vascepa, to thwart potential generic competition, Teva Pharmaceuticals has levied a similar challenge.

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STAT+: Up and down the ladder: The latest comings and goings

STAT

Hired someone new and exciting? Promoted a rising star? Finally solved that hard-to-fill spot? Share the news with us, and we’ll share it with others.  That’s right. Send us your changes, and we’ll find a home for them. Don’t be shy. Everyone wants to know who is coming and going. And here is our regular feature in which we highlight a different person each week.

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Pharmacy Focus: OTC Contraception and Reproductive Health

Pharmacy Times

Christin Hackel discusses the current state of OTC contraception options, the differences between OTC and prescription methods, and how pharmacists can promote education and awareness.

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To penetrate crowded GLP-1 field, Rivus Pharma is taking a metabolic approach

PharmaVoice

Rivus’ controlled metabolic accelerators are an emerging new potential competitor to popular weight loss and diabetes drugs from Novo Nordisk and Eli Lilly.

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The Role of GLP-1 Therapies in Type 2 Diabetes Prevention and Treatment

Compounding Pharmacy of America

An exploration of how proper diet, exercise, and a regiment of supplements combined with GLP-1 therapies can prevent and treat type 2 diabetes. The post The Role of GLP-1 Therapies in Type 2 Diabetes Prevention and Treatment appeared first on The Compounding Pharmacy of America.

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GAO Report on Clinical Research Inspections Encourages FDA to Care for its Clinical Inspection Program

The FDA Law Blog

By John W.M. Claud & Kalie E. Richardson — While Covid is in the rear view for most of us, FDA has had a tough time shaking off the effects of the pandemic on its inspection output. Inspections went down—way down—during the pandemic. In March 2020 , FDA temporarily postponed all foreign and domestic and routine surveillance facility inspections.

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Pharma Pulse 3/29/24: Social Media Users Turn to Twitter for Guidance on Birth Control, Wider Availability of Oral Contraceptives & more

Pharmaceutical Commerce

The latest news for pharma industry insiders.

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Brightside Health secures $33M to propel expansion into Medicare, Medicaid populations

Fierce Healthcare

Virtual mental health company Brightside Health picked up $33 million in fresh funding to help propel its expansion into Medicare and Medicaid populations. | Virtual mental health company Brightside Health picked up $33 million in fresh funding to help propel its expansion into Medicare and Medicaid populations.

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Arvinas gets grant for treatment of prostate cancer with specific compounds

Pharmaceutical Technology

Discover how Arvinas Inc's newly granted patent for compounds treating prostate cancer could revolutionize healthcare. Learn more about the potential for new drugs and therapies.

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Fierce Healthcare Fundraising Tracker—Staffing startup Float picks up series A; Tennr grabs $18M for fax automation

Fierce Healthcare

A new year brings a new approach to tracking health tech and digital health investments. | A roundup of health tech and digital health financing rounds in March. Check out who picked up new investments.

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Yield10 Bioscience gets grant for genetically engineered oilseed plant expressing plant protein

Pharmaceutical Technology

Discover the groundbreaking patent by Yield10 Bioscience Inc for a genetically engineered oilseed plant expressing a plant protein, revolutionizing biotechnology in agriculture.

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The backbone of breakthroughs: Insights into clinical trial supply management

pharmaphorum

Explore the key aspects of clinical trial supply management, including insights on Clinigen and its role in supporting clinical research trials. Learn how this backbone of breakthroughs can drive success in clinical trials.

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Today’s Most Promising Therapeutic Areas for Dealmaking

Pharmaceutical Commerce

In this Pharmaceutical Commerce video interview, Joerg Tritschler, a partner in Simon-Kucher’s life sciences division, discusses the hottest therapeutic settings for dealmaking activity at the moment—and one platform approach in particular poised to be at the center of future M&A and licensing pursuits.

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