Tue.Oct 01, 2024

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Diabetic Emergencies Led to Decreased Cardiovascular Events in Patients with Heart Failure

Drug Topics

Researchers compared the cardiovascular outcomes of patients hospitalized for heart failure that did or did not experience diabetic emergencies.

Hospitals 200
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Accelerated Radiation Therapy Course is Non-Inferior to Traditional Radiation in Patients Undergoing Breast Reconstruction

Pharmacy Times

The accelerated course was safe and effective and did not increase complications in patients with breast cancer post-mastectomy undergoing breast reconstruction.

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New analysis reveals postpartum sterilization rates are higher among U.S. women with sickle cell

STAT

Often, women with sickle cell disease are told not to have kids. They might come to an appointment, happily pregnant, only for the doctor to tell them they shouldn’t be. They might be preparing for a scheduled C-section when their OB-GYN says that this pregnancy has gone smoothly but the next one could kill them. The illness is associated with an increased risk of serious pregnancy complications, which warrants a discussion — but sometimes that discussion can blur the line between

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Big Pharma's layoff wave in New Jersey rolls on with hundreds of J&J cuts, 57 at Bayer

Fierce Pharma

Johnson & Johnson is laying off 231 employees in New Jersey and Bayer is cutting 57 positions in the state, according to separate Worker Adjustment and Retraining Notification (WARN)

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Q&A: NIAID’s Jeanne Marrazzo speaks on bird flu, mpox, and succeeding Anthony Fauci

STAT

A year ago last week, Jeanne Marrazzo stepped into a very big pair of shoes.  Marrazzo became the first new director of the National Institute of Allergy and Infectious Diseases in decades, taking over a job held for 38 years by Anthony Fauci, whose long-term status as a science god in Washington gave way to Covid-19 fall guy in some quarters during and after the pandemic.

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Angiotensin Neprilysin Inhibitors Could Benefit Patients with HFrEF

Drug Topics

Angiotensin neprilysin inhibitors have shown to reduce the risk of death and hospitalization due to heat failure, but high prescription costs are a current barrier.

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More Trending

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Wyden, Brown urge FTC to investigate PBM 'co-manufacturing' arrangements

Fierce Healthcare

Two key senators are urging the Federal Trade Commission to investigate "co-manufacturing" arrangements that they fear pharmacy benefit managers may be using to stymie competition. | Two key senators are urging the Federal Trade Commission to investigate "co-manufacturing" arrangements that they fear pharmacy benefit managers may be using to stymie competition.

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Why do Black Americans get more aggressive cancers?

STAT

Across all kinds of cancer, Black Americans have higher rates of mortality and, often, more aggressive forms of the disease. A growing body of research suggests the reasons may not have to do with African ancestry as much as social and environmental factors like racism, housing discrimination , and — according to a new study — exposure to pollution.

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Indoor Allergen Exposure Worsens Respiratory Infections in Children With Asthma

Pharmacy Times

A recent study found that indoor allergen exposure, including mouse and cockroach allergens, led to an increased risk of respiratory viral infections in children with asthma.

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Statins May Reduce Risk of Complications in Heart Transplant Recipients

Drug Topics

Two posters presented at the Heart Failure Society of America 2024 Annual Meeting looked deeper into the topic of statin use in heart transplant recipients.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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FDA Approves Ustekinumab-Aauz as Biosimlar for Stelara

Pharmacy Times

Ustekinumab is a human monoclonal antibody targeting the cytokines interleukin (IL)-12 and IL-23, which play a rule in the inflammatory and immune responses.

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Rippl announces $23M series A to expand virtual dementia care

Fierce Healthcare

Rippl, a virtual dementia care company, secured $23 million in series A funding to expand its services to patients in more states. | Rippl, a virtual dementia care startup, plans to use its series A funding to expand into new states, build out its value-based contracts and participate in CMS' GUIDE program.

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FDA Grants Rare Pediatric Disease Designation to BPM31510IV for Primary CoQ10 Deficiency

Pharmacy Times

Treatment for primary coenzyme Q10 (CoQ10) deficiency can include high-dose oral CoQ10 supplementation, but not all patients respond to this treatment.

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New analysis points to troubling trends as U.S. healthcare costs rise, but health outcomes worsen

Fierce Healthcare

A new analysis points to troubling trends in the U.S. healthcare market as costs continue to rise but health outcomes are declining. | "The inputs of the U.S. healthcare system, as measured by cost, exceed the outputs, as measured by the actual value or benefits received by Americans," Sanjula Jain, Ph.D., Trilliant Health's chief research officer, said.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Navenibart Receives FDA Orphan Drug Designation to Treat Hereditary Angioedema

Pharmacy Times

Navenibart was developed to aid treatment of hereditary angioedema (HAE) to provide swift and sustained HAE attack prevention through administration every 3 to 6 months.

FDA 121
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At-home hospital care popular with patients and clinicians, but data backing quality, costs are limited, CMS finds

Fierce Healthcare

Hospital programs providing at-home acute care are widely appreciated by patients and clinicians but still don’t have a bulletproof argument in respect to quality and costs as compared to a brick-a | A new 79-page government report on the soon-to-expire Acute Hospital Care at Home initiative outlines both clear-cut and muted wins for advocates.

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Real-World Data Confirms Protective Effects of SGLT-2 Inhibitors for Diabetic Kidney Disease

Pharmacy Times

The results validate the protective benefits of the sodium–glucose cotransporter-2 inhibitors on renal function for those with type 2 diabetes.

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STAT+: $400 million for an obesity drug startup? A new venture is a sign of the times

STAT

Atlas Venture and Bain Capital Life Sciences are making their next bet in the buzzy obesity field, launching a new startup led by a chief executive hot off of his third acquisition deal. Atlas, Bain, and RTW Investments announced Tuesday that they have co-led a $400 million Series A financing for a new Boston-area startup company called Kailera Therapeutics.

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The biggest opportunities for healthcare AI and the hurdles that stand in the way: Bessemer report

Fierce Healthcare

Bessemer Venture Partners released a new report that identifie | Bessemer Venture Partners has released a new road map outlining opportunities for artificial intelligence in healthcare. The VC firm also lists its six investing criteria for AI.

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Celebrate American Pharmacist Month

Pharmacy Times

Karen Merrill discusses her experiences in pharmacy with plans to celebrate her niece, a first-year pharmacist.

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Orlando Health closes $910M purchase of 5 Tenet Healthcare hospitals

Fierce Healthcare

Orlando Health has wrapped up its purchase of five Birmingham, Alabama-area hospitals’ majority ownership stakes from Tenet Healthcare, the systems announced Tuesday morning. | Brookwood Baptist Health is a Birmingham, Alabama-area joint venture with Baptist Health System, which remains a partner after Orlando Health's majority share purchase.

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Ensuring compliance - The Functional Point of Contact (FPOC) story

pharmaphorum

Learn how Advanced Clinical ensures compliance through the Functional Point of Contact (FPOC) story. Explore their innovative approach to maintaining regulatory standards.

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STAT+: U.S. lawmaker urges FDA to clarify drug patent listings in a key government registry

STAT

A U.S. lawmaker is pushing the Food and Drug Administration to provide more guidance on listing patents for drug-and-device combination products, such as asthma inhalers and auto-injectors for diabetes treatments, in a highly important agency registry known as the Orange Book. In a letter dated Monday, Sen. Bill Cassidy (R-La.) accused the FDA of failing to take responsibility for an issue that has long vexed a growing number of people over the implications for the availability of lower-cost gen

FDA 101
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GLP-1s May Protect Against Cardiovascular Outcomes Regardless of Diabetes Status

Drug Topics

Research presented at the Heart Failure Society of America 2024 Annual Meeting demonstrated that glucagon-like peptide 1 receptor agonists (GLP-1 RAs) reduced cardiovascular events in patients without diabetes.

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Microbiome startup Sequentia Biotech heralds “new era” in omics with €10 million round

Outsourcing Pharma

The Barcelona-based startup Sequentia Biotech has raised â10 million ($11 million) in a Series A round to finance the development of its omics-based technology for use in biomedicine, agritech and food.

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STAT+: The health care issues we’re watching in tonight’s VP debate

STAT

You’re reading the web edition of D.C. Diagnosis, STAT’s twice-weekly newsletter about the politics and policy of health and medicine.  Sign up here  to receive it in your inbox on Tuesdays and Thursdays. Not so Midwest nice Vice presidential debates don’t usually matter much, but this one might. It’s probably the last chance for a one-on-one matchup between the two parties’ tickets in a very close race.

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Authenticx CPO Eric Prugh on the impact of AI technology in pharmacovigilance

Outsourcing Pharma

Artificial intelligence has emerged as a potential solution to inconsistent reporting of adverse events, which to this day remains one of the main challenges in the field of pharmacovigilance.

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Opinion: STAT+: Five things FDA ad comm members want

STAT

As a public health professional, I want people to have access to the health care they need to improve their quality of life. For years I researched available treatments for specific illnesses to determine their safety and efficacy, growing to become an advocate for the development of new treatments for those living with rare diseases. Yet, for too long, I had no idea the Food and Drug Administration convenes groups of experts, known as advisory committees or ad comms, to review trial data for tr

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Pfizer gins up £2.4B after unloading hundreds of millions of Haleon shares

Fierce Pharma

Following a similar move in March, Pfizer is offloading another tranche of Haleon shares. | Pfizer has sold 640 million shares in Haleon for 380 pence (roughly $5.09) apiece. The sale amounts to a total value of 2.43 billion pounds sterling (about $3.26 billion) and follows a similar move in March.

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STAT+: Pharmalittle: We’re reading about CVS exploring a breakup, obesity drug coverage, and more

STAT

Top of the morning to you, and a fine one it is, despite the dreary gray skies hovering over the Pharmalot campus. We are doing our best to maintain sunny spirits, though, because once again, we recall some helpful wisdom from the Morning Mayor, who taught us that “every new day should be unwrapped like a precious gift.” To celebrate the notion, we are brewing still more cups of stimulation and inviting you to join us.

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Amid large cost-cutting drive, Pfizer plans manufacturing layoffs in Ireland

Fierce Pharma

No large pharma company has traversed this decade's ups and downs quite like Pfizer. | No large pharma company has traversed this decade's ups and downs quite like Pfizer. As the company rolls ahead with a large restructuring campaign, some staffers in Ireland will soon feel the effects.

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Struggle to regulate health AI, Epic’s antitrust challenges, and more AI news

STAT

You’re reading the web edition of STAT’s Health Tech newsletter, our guide to how technology is transforming the life sciences.  Sign up to get it  delivered in your inbox every Tuesday and Thursday. Abridge unveils new research collaborative with Epic, Stanford In an announcement shared exclusively with STAT, ambient documentation darling Abridge says it’s launching a new research effort to examine the technology’s impact on five dimensions: “ clinic

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BMS skates again on $6.4B Celgene shareholder lawsuit but is still not free from another filing

Fierce Pharma

For the second time in 19 months, a federal judge in New York has dismissed a lawsuit claiming that Bristol Myers Squibb slow-walked its request for FDA approval of blood cancer drug Breyanzi to av | For the second time in 19 months, a federal judge in New York has dismissed a lawsuit claiming that Bristol Myers Squibb slow-walked its request for FDA approval of blood cancer drug Breyanzi to avoid paying $6.4 billion to Celgene shareholders in contingent value rights.

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What is Marburg virus? Who is the new Fauci? And is your 3-year-old getting enough sleep?

STAT

Get your daily dose of health and medicine every weekday with STAT’s free newsletter Morning Rounds.  Sign up here. Good morning! We’ve got a vice presidential debate tonight. What do you think of the decision by CBS not to have moderators fact-check the candidates like ABC did for the presidential debate? (Watch this space tomorrow for a recap of health and medicine topics that come up.

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