Mon.Dec 18, 2023

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Assessing B-Cell Maturation Antigen Directed Therapies in Multiple Myeloma Treatment

Drug Topics

Three posters presented at the 65th American Society of Hematology Annual Meeting and Exposition looked into the efficacy and safety of the therapies.

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New Biomarker Shows Potential in Therapeutic Development for Alzheimer Disease

Pharmacy Times

Investigators analyzed the effects of harmful accumulation of HDAC6 in the brains of mouse models with Alzheimer disease to determine any changes in disease progression.

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Trending Sources

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STAT+: New Jersey’s telehealth restrictions cut off access to lifesaving care, lawsuit alleges

STAT

Since states started rolling back pandemic-inspired flexibilities that allowed physicians to easily practice telehealth across state lines, virtual health care providers have criticized state-based medical licensure rules as unnecessarily burdensome, expensive, and detrimental to patient care. Now, two of them are arguing in a lawsuit that they can also be unconstitutional.

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Researchers Evaluate New Advancements for RSV Management, Treatment

Pharmacy Times

The most recent advances included an approved vaccine that could immunize both the elderly and pregnant women, along with the release of nirsevimab.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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STAT+: ‘We’ve exhausted all avenues’: A small biotech may give up on its ultra-rare disease drug over frustration with FDA

STAT

Jamie Dubuque faces the future with a mixture of gratitude and trepidation. Her son, Declan, who turns 2 years old in January, survived a life-threatening episode of cardiac arrest that sent him to a hospital emergency room a year ago. But since being diagnosed with an ultra-rare disease, he has been treated with an experimental medicine that has transformed his day-to-day existence.

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Individuals Previously Infected with COVID-19 Face Increased Risk of Heart Rhythm Disruption

Pharmacy Times

Older individuals and individuals that experienced severe COVID-19 are at high risk of increased cardiac disturbances.

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More Trending

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Expert: The Evolution of HIV Care, Treatment Options, How Pharmacists Can Assist in Providing Care

Pharmacy Times

Using information from clinical studies and her experiences working in the field, Stephanie Kirk describes treatment options that are on the horizon, and how removing stigma is key in HIV care.

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Opinion: Alzheimer’s drug approvals show we need a reevaluation of patient advocacy

STAT

When faced with a loved one’s progressive neurodegenerative disease, like Alzheimer’s, or your child’s rare respiratory disease, you question why researchers and resource-backed pharma cannot bring a drug to market quickly enough to help your loved ones. Many people faced with this horror get involved to fight for better treatments.

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Trends shaping the pharmaceutical industry in 2024

PharmaVoice

Advancements in cloud and AI technology will transform clinical trial efficiency and engagement.

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STAT+: Prime Medicine, Mukherjee’s Myeloid Therapeutics clash over genome-editing deal

STAT

The closely watched gene-editing startup Prime Medicine is embroiled in a multimillion-dollar dispute with another biotech it partnered with to develop a potentially powerful new form of genome editing. Prime and Myeloid Therapeutics, a startup co-founded by Pulitzer Prize-winning writer and cancer biologist Siddhartha Mukherjee, have filed competing arbitration claims over a deal they signed in March 2022.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Kroger eyes opportunities in senior-focused primary care, rolls out service in Atlanta clinics

Fierce Healthcare

Kroger is piloting value-based primary care clinics as it joins a growing list of retailers looking to cash in on the booming sector of senior-focused medical care. | Kroger is piloting value-based primary care clinics as it joins a growing list of retailers looking to cash in on the booming sector of senior-focused medical care.

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STAT+: Wegovy may have another helpful trick: fighting inflammation via the brain, study finds

STAT

As more data emerges that obesity drugs like Wegovy can reduce complications from heart and kidney problems as well, scientists have been wondering whether these benefits are driven by weight loss alone or also by other mechanisms. A new study suggests that one possible contributor is the drugs’ ability to reduce inflammation independent of weight loss.

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To fight rare diseases, win the data battle first

pharmaphorum

To effectively combat rare diseases, it is essential to prioritise the collection and analysis of data. This article explores how pharmaceutical companies are leveraging AI and focusing on orphan drugs to tackle rare diseases.

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STAT+: Biden administration asks judge to toss out Humana’s Medicare Advantage audit lawsuit

STAT

The Department of Justice has asked a federal judge to dismiss a lawsuit brought by Humana, which alleged the government’s new audits of Medicare Advantage plans are unlawful. And if the lawsuit isn’t thrown out, the DOJ said in a new legal filing, at a minimum, it should be moved to a different federal court in Texas — away from a judge that has a track record of striking down federal health care laws.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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WeightWatchers rolls out telehealth clinic to prescribe weight loss drugs

Fierce Healthcare

WeightWatchers is adding its name to the growing list of companies providing telehealth weight loss management and access to buzzy GLP-1 medications. | WeightWatchers is adding its name to the growing list of companies providing telehealth weight loss management and access to buzzy GLP-1 medications.

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STAT+: Structure Therapeutics GLP-1 pill cuts blood sugar, weight in early diabetes study

STAT

Structure Therapeutics said Monday that its experimental GLP-1 pill demonstrated a 1% lowering of blood glucose and slightly more than 3% weight loss relative to a placebo in a 12-week study involving participants with type 2 diabetes — results that are preliminary but don’t quite match a competing oral drug under development by Eli Lilly.

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2024 Outlook: Will legislators pass meaningful reforms to PBMs? The jury is still out

Fierce Healthcare

There has been no shortage of conversation around pharmacy benefit managers this year, but actual action from legislators has been slow. | There has been no shortage of conversation around pharmacy benefit managers this year but actual action from legislators has been slow.

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Medication Adherence to BTK Inhibitors Can Pose Challenges for Patients With CLL

Pharmacy Times

Although treatment is effective, AEs remain difficult for patients.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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FDA Approves Updated LDL-C Lowering Indication for Esperion’s Nexletol, Nexlizet Tablets

Drug Topics

The federal agency also removed the maximally tolerated qualifier for statin use and the prior cardiovascular morbidity and mortality limitation of use statement.

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FDA Approves Enfortumab Vedotin, Pembrolizumab for Treatment of Urothelial Cancer

Pharmacy Times

The approval marks the first for an alternative to platinum-containing chemotherapy.

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STAT Virtual Event | Cancer’s Breakthrough Engine

STAT

Editor’s note: A livestream of the event will be embedded below at 1 p.m. ET. Since the development of Gleevec two decades ago, precision cancer medicines have become a driving force in biotech and a source of hope for cancer patients.

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2024 Outlook: How experts say payers will—or should—try to improve their Medicare Advantage star ratings

Fierce Healthcare

Payers need to properly adapt to changes made to the Medicare Advantage star ratings program or risk financial repercussions, industry experts told Fierce Healthcare. | Payers are being urged to prioritize health equity considerations more than ever before to improve their Medicare Advantage star ratings scores.

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Psilocybin-assisted therapy reduces depressive symptoms in cancer patients

European Pharmaceutical Review

Findings from a small Phase II clinical trial indicate that psilocybin, a hallucinogenic chemical found in certain mushrooms of the genus Psiloybe , may benefit individuals with cancer and major depression. The open-label trial involved 30 adults with cancer and major depression and was conducted by Sunstone Therapies in Rockville, Maryland. The participants each received a single 25mg dose of synthesised psilocybin, a one-to-one session with a therapist and group therapy support.

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A Look Back: The Life Sciences Industry in 2023 and a View for 2024

PharmExec

In the coming year, efficiency and automation will take center stage to maximize constrained resources but balancing sensible financial management with strategic investments will be vital.

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Illumina admits defeat in Grail quest, opting to divest

pharmaphorum

Illumina will divest cancer detection company Grail after losing an appeal in an antitrust court case in the US

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2024 Outlook: Drug price negotiations, Braidwood highlights top legal cases to watch

Fierce Healthcare

Legal experts indicated they will be paying close attention to lawsuits surrounding the Medicare drug price negotiation program and Braidwood v. | Preventative services covered under the Affordable Care Act and the Medicare drug price negotiations program are two legal questions that will play out next year.

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Eisai files biliary tract cancer drug tasurgratinib in Japan

pharmaphorum

Eisai files for approval in Japan for FGFR inhibitor tasurgratinib as a treatment for biliary tract cancers with FGFR2 gene fusions

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STAT+: Pharmalittle: Illumina will divest Grail after court finds deal was anti-competitive; FDA found problems at Moderna facility

STAT

Good morning, everyone, and welcome to another working week. We hope the weekend respite was relaxing and invigorating, because that familiar routine of online meetings and deadlines has predictably returned. But you knew this would happen, yes? To cope, we are firing up the coffee kettle and brewing another cup of stimulation. Our choice today is caramel brûlée.

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The Price of Prescriptions: Getting it Right

PharmExec

Drug companies face new hurdles in a rapidly changing marketplace. How do they finance new drug development amid the uncertainty?

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Does coffee affect your cholesterol?

The Checkup by Singlecare

For coffee lovers, your morning cup of joe is a way of life. The smell, the flavor, the caffeine—it’s all part of your daily ritual. If you’re in the “I love coffee” club, you’re not alone. According to NIH , 75% of Americans are coffee drinkers, and almost 50% of us drink it daily. Because coffee is so widely consumed you likely take time to think about how it affects your body in the long-term.

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CHMP backs Biogen’s Skyclarys for Friedreich’s ataxia

pharmaphorum

Biogen’s Skyclarys is on course to becoming the first approved medicine for the inherited neurological disease Friedreich’s ataxia (FA) in the EU after it was recommended by the EMA’s human medicines committee.

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Industry Voices—Premature babies deserve mature AI

Fierce Healthcare

In some healthcare settings, imperfect works for now. Clinicians in intensive care facilities, however, aren't able to accept imperfect AI.

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New RUBY readout buoys GSK’s Jemperli in endometrial cancer

pharmaphorum

RUBY Part 2 trial of GSK's PD-1 inhibitor Jemperli and PARP inhibitor Zejula could open up wider use in first-line endometrial cancer

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