Pharmaceutical Technology

NOVEMBER 24, 2022

The National Institute for Health and Care Excellence (NICE) in the UK has recommended Bristol Myers Squibb ’s (BMS) nivolumab (Opdivo) plus chemotherapy as an option for patients with advanced or metastatic gastric, gastro-oesophageal junction or oesophageal adenocarcinoma. The PD-1 protein can switch off the immune system of the body.

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Pharmaceutical Technology

NOVEMBER 13, 2022

The US Food and Drug Administration (FDA) has granted approval for AstraZeneca ’s Imfinzi (durvalumab) plus Imjudo (tremelimumab) and platinum-based chemotherapy to treat Stage IV (metastatic) non-small cell lung cancer (NSCLC) in adults.

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European Pharmaceutical Review

MAY 12, 2023

High-magnitude vaccine-induced T cell responses, the focus of the immune response analysis that included a new method to track vaccine-expanded clones, correlated with delayed PDAC recurrence. The personalised neoantigen vaccine was based on uridine mRNA–lipoplex nanoparticles. Rojas et al.

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pharmaphorum

JANUARY 26, 2023

More specifically, CAR-T cell therapy engineers a patient’s own immune cells (T-cells) to detect, target, and destroy cancer cells. After initial chemotherapy, up to 45% of patients with DLBCL will require a second line treatment, which often involves high-dose chemotherapy and a stem cell transplant.

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pharmaphorum

SEPTEMBER 13, 2022

Crucially, he observed a connection between certain tumours and inflammation, noting that neoplastic tissues were often covered with leukocytes of the immune system. 1942 – Chemotherapy moves from trenches to treatment . 1942 – Chemotherapy moves from trenches to treatment . 1907 – The magic bullet of immunotherapy.

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European Pharmaceutical Review

MAY 4, 2023

Amivantamab was the first bispecific monoclonal antibody (BsMAb) approved in the EU to treat advanced NSCLC with EGFR exon 20 insertion mutations post chemotherapy. Overall, the mechanisms of action for amivantamab include ligand blocking, receptor degradation, and immune cell-mediated activity. Oral Presentation JGN-75414.

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pharmaphorum

JANUARY 19, 2022

EQRx’s GEMSTONE-302 study evaluated the efficacy and safety of the investigational anti-PD-L1 antibody, sugemalimab, in combination with chemotherapy as a first-line treatment for patients with stage four non-small cell lung cancer (NSCLC), versus using chemotherapy alone.

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European Pharmaceutical Review

DECEMBER 28, 2023

As well as presenting recent findings from the pivotal AFM13-104 study, Andreas also reflects on the challenges encountered and conquered in developing Affimed’s innate cell engager, Acimtamig, which targets CD30 on lymphoma cells and CD16A on NK cells. Can you share some highlights from the data presented at ASH 2023?

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pharmaphorum

AUGUST 18, 2022

In presentations and published abstracts, researchers shared a massive amount of data across all cancer types and treatment modalities. Researchers also dove into socio-economic disparities in cancer care. Below are just a few of the highlights from the show.

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pharmaphorum

JANUARY 26, 2023

The cancer is particularly challenging for immunotherapy, as it tends to have fewer mutations than other cancers, presenting fewer targets for immune cells, and tends to be immunologically ‘cold’, with few immune cells infiltrating the tumour. It remains ongoing with updated results due in the coming months.

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pharmaphorum

NOVEMBER 29, 2022

Amplifying and reinvigorating persistent T cell immunity has become a much-needed path to enhance anti-tumor efficacy. T cells are known to mediate anti-tumor immune responses. For that reason, they have become the key target of immune checkpoint therapies, like PD-(L)1 agents.

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European Pharmaceutical Review

APRIL 10, 2024

When collecting stool, experts will also consider the amount of microorganisms present, and their potential variety and diversity, to understand the overall health and function of the individual donor’s microbiome. Notably, from one donor to another, significant variations exist.

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The Checkup by Singlecare

SEPTEMBER 12, 2023

The Shingrix vaccine triggers the immune system to respond to the varicella virus and suppress the outbreak of shingles,” says David Cutler , MD, a family medicine physician at Providence Saint John’s Health Center in Santa Monica, California. This is a typical immunization response as your body builds a defense against possible infection.

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Pharmaceutical Technology

SEPTEMBER 13, 2022

The advent of immune checkpoint inhibition has arguably been the greatest breakthrough for the treatment of metastatic solid tumours, with durable complete responses observed across multiple cancer types. month progression-free survival (PFS) benefit over SOC chemotherapy. MSI-H/dMMR CRC accounts for 10-15% of all CRC.

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Hospital Pharmacy Europe

FEBRUARY 6, 2023

Other recognised causes or insults he mentioned include certain drugs, e.g., some of those used in chemotherapy, as well as both bacterial and fungal infections. In such cases, patients would normally present with shortness of breath. Finally, myocarditis may occur because of systemic infections such as sepsis.

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PQA

NOVEMBER 1, 2024

Monitoring Oral Chemotherapy Outcomes A new study by specialty pharmacists from Vanderbilt Specialty Pharmacy detailed that a tailored clinical monitoring schedule focused on oral oncolytics with high rates of adverse events (AEs) slashed treatment interruptions by more than 50% and significantly reduced medication-related hospitalizations.

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Hospital Pharmacy Europe

AUGUST 29, 2024

After focusing on bone marrow transplantation as part of her specialist medical training, Dr Sara Ghorashian was curious about developing a more precise tool to utilise the immune system to fight cancer. These patients often reach the ceiling for toxicity in terms of chemotherapy and radiotherapy in the context of a bone marrow transplant.

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European Pharmaceutical Review

JULY 13, 2022

Our work is establishing whether it is possible to use allogeneic innate immune cells from a healthy donor to support the immune system of a person with cancer in combatting the condition. T cells are the first line of defence in the immune system to eradicate diseases. such as a chimeric antigen receptor (CAR). In response, ??

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BuzzRx

OCTOBER 26, 2022

The other type of leukemia classification is based on the type of white blood cell involved: Lymphocytic leukemias affect lymphoid cells, which are part of the body’s immune system. Doctors can diagnose chronic leukemias through routine blood work even before any symptoms are present. What are the four main types of leukemia?

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Hospital Pharmacy Europe

SEPTEMBER 29, 2022

Neoadjuvant therapy (NAT) a few weeks before surgery in patients with DNA mismatch repair deficient (dMMR) colon cancer gave rise to a major pathologic response of 95% according to the findings by Dutch researchers presented at the recent European Society of Medical Oncology Congress. ’ Citation Chalabi M et al.

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European Pharmaceutical Review

JUNE 27, 2023

Positive topline data from Phase IIb trial and data from 81 patients with aGvHD in Early Access Program have been presented at American Society of Hematology (ASH) annual meetings, respectively in 2021 and 2022. How do you envision microbiome therapies complementing existing cancer treatments, such as chemotherapy and immunotherapy?

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BuzzRx

JANUARY 29, 2023

You can catch the flu multiple times because the viruses keep changing (mutating) and your body does not have immunity to the newer versions. The flu virus is present in tiny droplets from the nose and mouth when an infected person sneezes or coughs. It is especially common during the winter months or flu season.

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pharmaphorum

DECEMBER 21, 2020

Data from trials of the drug wowed ESMO in September – Trodelvy was shown to significantly extend overall survival (OS) and improved overall response rate (ORR) and clinical benefit rate (CBR), compared with standard chemotherapy in TNBC patients with brain metastases treated with at least two therapies. months, compared with 6.7

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pharmaphorum

JUNE 8, 2021

At present, innovation resources in most Asian countries and regions have not been translated into a sizeable global market share; neither the world nor the local countries and regions have fully benefited from the innovative activities of biopharmas in this region,” he says. “If Chemotherapy still accounted for 72.6% million in 2030.

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pharmaphorum

MARCH 16, 2021

The company highlighted data presented at the online European Society for Blood and Marrow Transplantation 2021 conference from the Starbeam ALD study involving the gene therapy known as elivaldogene autotemcel, known for short as eli-cel or Lenti-D. There is only safety data available so far due the limited follow-up duration of 8.6

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Hospital Pharmacy Europe

AUGUST 17, 2023

In the last decade, immunotherapies that treat cancers using the patient’s immune system to recognise, attack and kill malignant cells have reached the market. Cancer is one of the leading causes of death globally, and improving therapeutic strategies in haematology and oncology remains a priority in healthcare.

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The Checkup by Singlecare

JANUARY 22, 2023

Rheumatoid arthritis (RA) is a chronic, autoimmune disease that occurs when the body’s immune system attacks its tissues. Concurrent use of corticosteroids, anticoagulants , antiplatelets, chemotherapy, tobacco, and alcohol can increase the likelihood of these GI side effects. RA can occur at any age, even in children.

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BuzzRx

NOVEMBER 18, 2022

If you have certain health conditions or are taking medications that weaken the immune system, treatment is almost always warranted, as your body cannot clear infections well enough compared to others. Topical antifungals are also used to eliminate the fungus present deep inside the hair follicle. Should you pop folliculitis bumps?

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The Checkup by Singlecare

FEBRUARY 16, 2024

“ Rosacea typically presents as red papules or pustules on the mid-face, whereas traditional acne can present as red papules, pustules, or nodules on the face, neck, chest, and back,” Bunick says. ” Birthmarks may be present at birth or may develop in very early childhood.

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Roots Analysis

OCTOBER 4, 2023

They are designed to recognize and bind to two specific molecules, such as a tumor cell and an immune cell, or two different parts of the same molecule. Following table presents information on all the bispecific antibodies approved, till now, along with their approval dates and target indications.

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Roots Analysis

OCTOBER 24, 2023

Hence, they are commonly used in the treatment of cancer, as part of the chemotherapy regime. Besides cancer, they are also increasingly being used for other medical conditions such as rheumatoid arthritis, multiple sclerosis and other auto immune disorders. They can also inhibit or prevent the function of cells.

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PharmaShots

MARCH 29, 2023

The drug selectively inhibits the phosphorylation of VEGFR cells, c-kit and PDGFR-ß As of now, there are no generic versions available for the drug at present. It is the only drug in its class of chemotherapy and is developed from the natural substance found in a sea sponge.

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The Checkup by Singlecare

FEBRUARY 8, 2024

While it can be used to manage many mental health conditions, including bipolar disorder and schizophrenia , it also plays a role in the prevention and treatment of chemotherapy-induced nausea and vomiting. Effects on the central nervous system include headache, impaired memory, and reduced cognitive dysfunction.

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Pharmaceutical Technology

MARCH 6, 2023

Patients in the US and EU with recurrent or metastatic nasopharyngeal carcinoma (NPC), a subtype of head and neck squamous cell carcinoma (HNSCC), are mostly treated with a combination of chemotherapy agents in the frontline setting, such as cisplatin + gemcitabine. months for the chemotherapy arm (hazard ratio [HR]: 0.52).

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The Thyroid Pharmacist

SEPTEMBER 20, 2024

[1] The Rome IV Diagnostic Criteria (a system developed to classify the functional gastrointestinal disorders) for chronic constipation, states that these symptoms must be present for six months or greater, and must accompany at least 25 percent of bowel movements in the last three months. pylori or low thyroid function is present. [89]

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The Thyroid Pharmacist

NOVEMBER 4, 2022

Myo-inositol is a form of inositol, a type of natural sugar alcohol that’s present in mammalian cells. 28) The same authors also found TPO antibodies present in 27 percent of patients with PCOS, versus 8 percent in controls. Brain Behav Immun. Hypothyroidism Presenting as Psychosis: Myxedema Madness Revisited.

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The Thyroid Pharmacist

JULY 8, 2022

Selenium is vital to our body’s ability to convert T4 to T3, and has a balancing effect on our thyroid and immune health. There are many different types of selenoproteins that focus on different functions relating to thyroid and immune system support. Why such an impact on so many? This is how autoimmunity starts.

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