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Hospital Universitario and Josep Carreras develop cell therapy for leukaemia

Pharmaceutical Technology

Spain’s Hospital Universitario 12 de Octubre researchers, along with the Josep Carreras Leukaemia Research Institute, have developed a new cell therapy based on STAb cells to treat a type of leukaemia. The post Hospital Universitario and Josep Carreras develop cell therapy for leukaemia appeared first on Pharmaceutical Technology.

Hospitals 110
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ESMO: TIL therapy improves on Yervoy in melanoma trial

pharmaphorum

With the results in hand, the developers of the therapy – from the Netherlands Cancer Institute and Norway’s National Center for Cancer Immune Therapy – say they now intend to file for regulatory approvals in Europe before the end of the year, without a commercial partner “to try to ensure that it remains affordable.”

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NICE recommends first CAR-T cell therapy on NHS in England

pharmaphorum

More specifically, CAR-T cell therapy engineers a patient’s own immune cells (T-cells) to detect, target, and destroy cancer cells. After initial chemotherapy, up to 45% of patients with DLBCL will require a second line treatment, which often involves high-dose chemotherapy and a stem cell transplant.

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EMA grants mitazalimab orphan drug designation for pancreatic cancer

Hospital Pharmacy Europe

A human CD40 agonistic antibody targeting CD40, mitazalimab kickstarts the cancer-immunity cycle by priming and activating tumour-specific T cells. Targeting CD40 with mitazalimab has the potential to augment responses to chemotherapy. A median duration of response of 8.7 months was also reported.

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Novartis extends Kaiku digital patient monitoring partnership

pharmaphorum

In May, a Phase 2 study started, comparing Kaiku’s electronic patient-reported outcome (ePRO) approach to evaluating immune-related adverse events to the standard model of care in cancer patients treated with checkpoint inhibitor drugs, with results due towards the end of 2023 or in early 2024.

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Integrating personalised colorectal cancer vaccines into the evolving treatment landscape

Hospital Pharmacy Europe

The idea of cancer vaccines is not new, but Dr Victoria Kunene, consultant medical oncologist at Queen Elizabeth Hospital Birmingham, UK, is leading the charge in their latest iteration: personalised preventative and therapeutic mRNA vaccines against colorectal cancer. Of course, we’ve also had the advent of immune checkpoint inhibitors.

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Meet the Expert: Myocarditis

Hospital Pharmacy Europe

Sanjay Prasad MD has been a consultant in cardiology and cardiovascular magnetic resonance at the Royal Brompton Hospital since 2003 and is also Professor of Cardiomyopathy at Imperial College, London. In contrast, in drug-related causes, especially chemotherapy, patients were generally aged 50–60 years. Reference Lota As et al.