STAT

SEPTEMBER 8, 2023

A large independent group of oncologists in Philadelphia is suing the area’s dominant hospital system, Jefferson Health, alleging the system is violating federal antitrust and kickback laws by creating a “concerted campaign to eliminate” the group’s “presence in the oncology marketplace.”

Hospitals 137

Hospitals Chemotherapy Insurance 137

STAT

SEPTEMBER 14, 2023

WASHINGTON — A nonprofit formed by hospitals to deal with drug shortages is considering a move into chemotherapies. Frustrated by drug shortages and the price spikes that typically ensue, executives from large hospital systems launched the nonprofit Civica Rx to deal with the problem in September 2018.

Chemotherapy 133

Chemotherapy Hospitals 133

Pharmaceutical Technology

JANUARY 17, 2023

Spain’s Hospital Universitario 12 de Octubre researchers, along with the Josep Carreras Leukaemia Research Institute, have developed a new cell therapy based on STAb cells to treat a type of leukaemia. The post Hospital Universitario and Josep Carreras develop cell therapy for leukaemia appeared first on Pharmaceutical Technology.

Hospitals 110

Hospitals Chemotherapy Communication Immunization 110

STAT

FEBRUARY 14, 2024

The Federal Trade Commission is launching a probe into the extent to which group purchasing organizations and wholesalers may contribute to ongoing shortages of key medicines at hospitals and other facilities across the country. Three group purchasing organizations, or GPOs, buy drugs on behalf of most hospitals in the U.S.,

Nursing Homes 142

Nursing Homes Chemotherapy Hospitals 142

STAT

OCTOBER 20, 2023

Pharmacists increasingly are being asked to make drugs in bulk for hospitals that are in short supply, and they’re even beginning to make chemotherapies. Hospitals’ reliance on pharmacist-made drugs, a practice called compounding, has risen in step with worsening drug shortages.

Compounding 129

Compounding Chemotherapy Hospitals 129

STAT

SEPTEMBER 21, 2023

Like many cancer patients, Sarah’s treatment at Dana-Farber was co-managed by its longtime medical partner, Brigham and Women’s Hospital: Her three surgeries were performed at the Brigham, by Brigham doctors; her five rounds of chemotherapy at Dana-Farber.

Chemotherapy 142

Chemotherapy Hospitals 142

STAT

APRIL 11, 2024

Diagnosed at age 3 with acute myeloid leukemia, an aggressive blood cancer, Logan happened to have a targetable mutation that occurs in a small minority of childhood AML cases, making it possible for him to receive a precision therapy drug that — with chemotherapy — got him to a point where he could receive a bone marrow transplant.

Chemotherapy 145

Chemotherapy Hospitals 145

Outsourcing Pharma

AUGUST 4, 2023

Scientists at a major US hospital have developed a âcancer-killing pillâ that appears to âannihilateâ solid tumors through targeted chemotherapy.

Chemotherapy 96

Chemotherapy Hospitals 96

Hospital Pharmacy Europe

FEBRUARY 14, 2023

The use of neoadjuvant chemotherapy has been shown to be of value at reducing tumour size and stage in patients with other operable cancers such as gastric and lower oesophageal adenocarcinomas. Neoadjuvant chemotherapy and cancer surgery outcomes A total of 686 patients assigned to NAC and 351 control patients were included in the analysis.

Chemotherapy 52

Chemotherapy Hospitals 52

pharmaphorum

NOVEMBER 28, 2021

The three-year phase 2 trial will be carried out by researchers at Leeds University led by professor of clinical oncology and neuro-oncology Susan Short, and see if adding Sativex (nabiximols) to standard chemotherapy for recurrent glioblastoma can extend survival. Jazz acquired rights to Sativex when it completed its $7.2

Chemotherapy 136

Chemotherapy FDA Hospitals 136

STAT

OCTOBER 5, 2023

Based on questions posed to 29 of its 33 member hospitals, the National Comprehensive Cancer Network said Thursday that 86% of those cancer centers are experiencing a shortage of at least one type of generic chemotherapy drug, down from 90% in May.

Chemotherapy 127

Chemotherapy Hospitals 127

STAT

JUNE 28, 2023

“Oftentimes we can cure kids of their disease, but we can’t do that without the drugs,” said Unguru, a pediatric hematologist oncologist at Children’s Hospital at Sinai in Baltimore and the Johns Hopkins School of Medicine. “It’s just so, so maddening.”

Chemotherapy 106

Chemotherapy Hospitals 106

Hospital Pharmacy Europe

JANUARY 24, 2024

The final draft guidance from NICE recommends talazoparib for the treatment of adults with BRCA 1 or 2 mutated HER2-negative locally advanced or metastatic breast cancer after prior chemotherapy. Evidence from a clinical trial showed that talazoparib increases how long people live without their cancer getting worse compared with chemotherapy.

Chemotherapy 101

Chemotherapy Hospitals 101

Hospital Pharmacy Europe

JANUARY 23, 2025

The approach was adopted widely, particularly for cytotoxic chemotherapy agents, with the aim of standardising drug exposure and minimising toxicity. 5,6 Freireich et als work further validated this approach, showing that BSA correlated with drug efficacy and toxicity across several chemotherapy agents. 6 Gurney H.

Chemotherapy 64

Chemotherapy Hospitals Dosage Pharmaceutical Companies 64

European Pharmaceutical Review

OCTOBER 1, 2022

A Phase III trial from Shanghai Henlius Biotech is the first study to suggest that the programmed cell death (PD) 1 receptor immune checkpoint inhibitor Hansizhuang (serplulimab) plus chemotherapy can markedly improve survival for extensive-stage small cell lung cancer (ES-SCLC) patients.

Chemotherapy 98

Chemotherapy Immunization Hospitals 98

The Checkup by Singlecare

JUNE 17, 2024

When over-the-counter (OTC) remedies don’t cut it, your healthcare provider may prescribe Zofran ( ondansetron ), a medication used to treat upset stomach and prevent vomiting—especially when caused by chemotherapy, radiation therapy, and surgery. It’s also can be used off-label to treat morning sickness during pregnancy.

Chemotherapy 105

Chemotherapy Dosage Packaging Hospitals 105

Hospital Pharmacy Europe

AUGUST 30, 2022

Currently, it is recommended that stage I disease is treated with radiotherapy alone whereas concurrent chemotherapy (i.e., Despite the recommendation to combine IMRT and chemotherapy for patients with stage II NPC, there is a lack of supportive evidence for this approach. chemoradiotherapy) is advised for patients at stage II.

Chemotherapy 52

Chemotherapy Hospitals 52

STAT

OCTOBER 5, 2022

She was rushed to the hospital, where doctors diagnosed the then 29-year-old with a brain tumor. After the brain tumor diagnosis in 2016, Gatton would undergo two brain surgeries, radiation treatment, chemotherapy, followed by an embryo transfer that failed.

Chemotherapy 106

Chemotherapy Hospitals 106

pharmaphorum

JULY 5, 2022

Cancer drugs will be flown from a facility in Portsmouth to a hospital on the Isle of Wight by drone, in the first pilot study of the technology by NHS England. The Solent pilot will be followed by another pilot in Northumbria, once again focusing on deliver of chemotherapy agents.

Chemotherapy 105

Chemotherapy Hospitals 105

STAT

JULY 18, 2023

WASHINGTON — Medicare has a new proposal to pay hospitals more to stockpile essential drugs — an idea that comes as doctors report running low on critical chemotherapies and other drugs. But Medicare has its own new idea: paying hospitals to create a “buffer stock” of 86 medicines that HHS deems critical.

Hospitals 98

Hospitals Chemotherapy FDA 98

Hospital Pharmacy Europe

SEPTEMBER 11, 2024

Professor Alain Astier discusses how the tradition of manufacturing drugs in hospitals and hospital pharmacies is taking on new directions in light of increasing medicine shortages, enhanced professional responsibilities for pharmacists and the shift towards delivering personalised medicine. Making drugs is old-fashioned!

Hospitals 52

Hospitals Community Pharmacies Pharmaceutical Companies Pharmaceutical Companies 52

STAT

SEPTEMBER 25, 2023

For months, oncologist Kristen Rice found herself scrambling for cisplatin and carboplatin, two key chemotherapies used for many different cancers including ovarian, bladder, and lung cancer. We went to put in our chemotherapy order, and our supplier said, ‘We don’t have any.’ “It came without warning.

Chemotherapy 139

Chemotherapy Hospitals 139

STAT

AUGUST 11, 2023

Fifty-seven percent of hospital pharmacists said they are facing critical shortages of chemotherapy drugs in a new survey from the American Society of Health-System Pharmacists. Hospital pharmacists also reported significant shortages of steroids, hormonal drugs, and oral liquids such as amoxicillin and lidocaine.

Chemotherapy 98

Chemotherapy Hospitals 98

European Pharmaceutical Review

NOVEMBER 9, 2023

The European Commission (EC) has authorised the anti-cancer treatment in combination with standard cytarabine and anthracycline induction and standard cytarabine consolidation chemotherapy, followed by VANFLYTA single-agent maintenance therapy for adult patients with newly diagnosed acute myeloid leukaemia that is FLT3 -ITD positive.

Chemotherapy 98

Chemotherapy Hospitals 98

European Pharmaceutical Review

NOVEMBER 24, 2022

s Libtayo ® (cemiplimab) for adults with recurrent or metastatic cervical cancer and disease progression while on or after platinum-based chemotherapy. “Libtayo ® was the first programmed cell death protein (PD)-1 inhibitor to demonstrate significant improvements in survival compared to chemotherapy in a Phase III trial.

Chemotherapy 98

Chemotherapy Immunization Adverse Reactions Hospitals 98

Hospital Pharmacy Europe

SEPTEMBER 1, 2023

However, where patients are receiving intravenous chemotherapy in combination with atezolizumab, they may remain on the transfusion. While the IMscin001 trial was conducted within the hospital setting, Roche has said that SC atezolizumab may also be suitable for out-of-hospital administration by a healthcare professional.

Chemotherapy 98

Chemotherapy Hospitals FDA 98

Hospital Pharmacy Europe

AUGUST 2, 2023

This global, multi-centre, open-label, Phase 3 study, evaluated Trodelvy versus the physician’s choice of chemotherapy (eribulin, capecitabine, gemcitabine or vinorelbine). as assessed by blinded independent central review for participants treated with Trodelvy compared to those treated with chemotherapy.

Chemotherapy 86

Chemotherapy Labelling Hospitals 86

pharmaphorum

JANUARY 3, 2023

Over recent years, there has been a growing consensus that using chemotherapy and aggressive treatments towards the end-of-life should be avoided, where possible, due to the lower quality of life reported. Once no cure can be found for a patient’s condition, decisions must be made about what is the most suitable path forwards.

Chemotherapy 105

Chemotherapy Immunization Hospitals 105

Hospital Pharmacy Europe

AUGUST 15, 2023

Participants with resectable stage II, IIIA, or IIIB NSCLC, were randomised 1:1 to receive neoadjuvant pembrolizumab (200 mg) or placebo once every three weeks, each of which was given with cisplatin-based chemotherapy for four cycles, followed by surgery and adjuvant pembrolizumab (200 mg) or placebo once every three weeks for up to 13 cycles.

Chemotherapy 96

Chemotherapy Immunization Hospitals 96

Pharmaceutical Technology

NOVEMBER 29, 2022

Darolutamide is administered as a tablet along with androgen-deprivation therapy (ADT) and docetaxel chemotherapy. According to data from the ARASENS clinical trial carried out at nearly 300 sites globally, including various NHS hospitals, subjects who received the combination therapy had a 32.5%

Chemotherapy 118

Chemotherapy Hospitals 118

European Pharmaceutical Review

APRIL 3, 2023

In the Phase I New Approaches to Neuroblastoma Therapy (NANT) trial, researchers found that lorlatinib given alone or in combination with chemotherapy was safe and tolerable in patients with relapsed/refractory anaplastic lymphoma kinase (ALK)-driven neuroblastoma. However, it held promise when given in combination with chemotherapy. “As

Chemotherapy 97

Chemotherapy Hospitals FDA 97

pharmaphorum

SEPTEMBER 11, 2022

The patient then receives chemotherapy to reduce regulatory T cells that can put a brake on immune responses to tumours, as well as immune-boosting cytokine interleukin-2, before the TILs are then reinfused into the patient intravenously. “The findings raise hopes for the management and potential cure of metastatic solid tumours.”

Immunization 105

Immunization Chemotherapy Hospitals 105

pharmaphorum

JANUARY 26, 2023

Yescarta is administered to the patient via a single intravenous infusion following the administration of a round of chemotherapy designed to accommodate the new cells and minimise the patient’s immune reaction to them. About 50% will ultimately relapse post-transplant. Since then, over 500 patients in England have received axi-cel.

Chemotherapy 96

Chemotherapy Immunization Hospitals 96

Hospital Pharmacy Europe

AUGUST 17, 2023

Guidance on the provision of CAR T and cellular therapy services in hospital pharmacy has been published by the GoCART Coalition to harmonise implementation across Europe. 10 Once the CAR T-cells are manufactured, they are delivered to hospital pharmacies, making pharmacists central in ensuring appropriate governance and management.

Hospitals 98

Hospitals Documentation Chemotherapy Pharmaceutical Companies 98

pharmaphorum

MAY 20, 2021

Hormone-sensitive metastatic prostate cancer is usually treated with docetaxel chemotherapy plus ADT, or ADT alone in patients who are not suitable for chemotherapy. Hormone relapsed disease has stopped responding to hormone therapy and is usually treated with ADT alone or with Bayer’s Nubeqa (darolutamide) and ADT.

Chemotherapy 98

Chemotherapy Hospitals 98

Hospital Pharmacy Europe

AUGUST 23, 2023

Targeting CD40 with mitazalimab has the potential to augment responses to chemotherapy. Mitazalimab and OPTIMIZE-1 Mitazalimab is currently being evaluated in the phase 1b/2 OPTIMIZE-1 trial in combination with mFOLFIRINOX chemotherapy for adult patients with previously untreated metastatic PDAC. A median duration of response of 8.7

Chemotherapy 98

Chemotherapy Immunization Hospitals FDA 98

STAT

OCTOBER 28, 2022

The move comes as hospitals grapple with persistent shortages of fludarabine, an older chemotherapy used in the run-up to bone marrow transplants in patients with a form of leukemia and CAR-T cell therapy. Continue to STAT+ to read the full story…

Chemotherapy 98

Chemotherapy Dosage Hospitals 98