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FDA drug dosage optimisation guidelines signal clinical trial reform

Pharmaceutical Technology

In January, amidst calls to improve patient safety by optimizing licensed drug formulations, the FDA released a draft guidance that signalled a departure from the most commonly used method of identifying a new therapy’s ideal dosage. The focus on identifying the ideal drug dosage is not new. What is drug dose optimisation?

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How long does Zofran take to work?

The Checkup by Singlecare

When over-the-counter (OTC) remedies don’t cut it, your healthcare provider may prescribe Zofran ( ondansetron ), a medication used to treat upset stomach and prevent vomiting—especially when caused by chemotherapy, radiation therapy, and surgery. The dosage form impacts how long Zofran takes to kick in.

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Ondansetron for cats: Dosage and safety

The Checkup by Singlecare

The most common reasons ondansetron is needed in cats are chemotherapy, drug treatment, and pancreatitis (inflamed pancreas). Chemotherapy and drug-induced vomiting Like dogs and humans, cats can get malignant cancers that require chemotherapy. As in humans, doses may be given both before and after chemotherapy.

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Ondansetron for dogs: Dosage and safety

The Checkup by Singlecare

In human patients, it’s used to treat vomiting and nausea due to cancer chemotherapy or radiation therapy. Veterinarians commonly use ondansetron for chemotherapy, but its use in dogs is “ off-label.” Nausea-inducing chemotherapy is a common reason veterinarians give dogs ondansetron. Dosages also vary depending on the source.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

A recent draft from the FDA provides valuable insight.

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Drug Formulation In-Depth Focus 2022

European Pharmaceutical Review

Cyclodextrins are a frequently used excipient in the pharmaceutical industry, employed in multiple dosage forms and with multiple purposes simply because of their numerous positive properties, including being generally well tolerated and safe. Could the new wave of taxane chemotherapies succeed where traditional chemotherapies have failed?

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Cymbalta generic availability, cost, and dosage

The Checkup by Singlecare

Chemotherapy-Induced Peripheral Neuropathy Studies have shown that duloxetine may help prevent or reduce nerve pain in people who have been treated with chemotherapy. The post Cymbalta generic availability, cost, and dosage appeared first on The Checkup.

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