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Tackling immune-mediated disease with CAR Tregs

European Pharmaceutical Review

Recognising the potential of CAR T cells to act as highly targeted therapeutics, several biotechnology companies – including Sangamo Therapeutics – have established development pipelines of CAR T regulatory cells (Tregs) that aim to tackle immune?mediated What are Tregs and how are they applicable to immune-mediated disease?

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Alzheimer’s vaccine granted Fast Track designation

European Pharmaceutical Review

AC Immune SA has received Fast Track designation from the US Food and Drug Administration (FDA) for its anti-amyloid beta (Abeta) active immunotherapy vaccine candidate for Alzheimer’s disease. The anti-Abeta therapy “specifically targets the most toxic forms of Abeta” according to Dr Andrea Pfeifer, CEO of AC Immune SA.

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Is albumin the key to successful nasal vaccines?

European Pharmaceutical Review

The University of Minnesota researchers tested the technology on mice and non-human primates and found that the vaccine generated strong immune responses, paving the way for further study and development of nasal vaccines. This is because they can trigger immune responses in the primary areas of infection – the nose, mouth and lungs.

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Optimum timing for beclomethasone inhaler use identified by researchers

Hospital Pharmacy Europe

Conducted at the Medicines Evaluation Unit at Wythenshawe Hospital and funded by the Jon Moulton Charity Trust, this study builds on previous research by the same team , which found that immune cells displayed heightened steroid sensitivity at 4pm compared to 4am.

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7 health benefits of raspberry leaf tea

The Checkup by Singlecare

Antioxidants are often associated with a healthy immune system, but they may also stave off disease by protecting cells from damage caused by free radicals. Its anti-inflammatory benefits to oral mucosal conditions may be due to the presence of tannins and flavonoids, a review article suggests.

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Intratumoural viral delivery improves glioblastoma survival

European Pharmaceutical Review

The viral therapy “aims to awaken the patient’s immune system and trigger a healing from within,” Dr Fueyo commented. After injection, patients that respond well develop inflammation inside the tumour, triggering an immune response that first kills the virus.” This makes it difficult to treat the cancer with immunotherapy.

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Cancer vaccines: providing the edge in oncology

pharmaphorum

In this article, Ben Hargreaves looks into the promise of cancer vaccines and how this treatment modality may offer advantages over existing immunotherapies in the oncology sector. While therapeutic cancer vaccines are able to help the body identify particular proteins expressed by cancer cells and then to instigate an immune response.

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