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Considerations for a Decentralized Manufacturing Paradigm

ISPE

POD is suitable for a wide range of products, including oral solid dosage forms, mAbs, and cell therapy. Review: Continuous Manufacturing of Small Molecule Solid Oral Dosage Forms.” The fit-for-purpose and reduced-size POD units promote green manufacturing. Journal of Biotechnology 213 (2015):120–30. doi:10.1016/j.jbiotec.2015.06.388

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Contamination Trends & Proposed Solutions

ISPE

35 Cross-contamination involving vincristine also led to neurologic symptoms such as weakness and paralysis in at least 107 patients across 12 hospitals in China, despite investigations revealing that vincristine was only present in trace amounts between 0.28 and 18 micrograms per milliliter. 33 2 a b c d e f Bharate, S. Morikawa, M.