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EU first to clear Roche’s lymphoma bispecific mosunetuzumab

pharmaphorum

Patients also have to undergo lymphodepleting chemotherapy to help prepare the body for the CAR-T cells. With Lunsumio, patients do not have to wait to start treatment and avoid the need for chemotherapy, which can sometimes not be an option at all for people who are frail.

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STAT+: Pharmalittle: We’re reading about 23andMe retrenching, AstraZeneca reworking cancer drug plans, and more

STAT

The medicine, Dato-DXd, is a type of next-generation chemotherapy called an antibody-drug conjugate that AstraZeneca and other companies are investing in heavily.   AstraZeneca had to resubmit a closely watched medicine for U.S.  Finally, AstraZeneca plans to invest $3.5 Continue to STAT+ to read the full story…

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Roche, Blueprint’s RET cancer drug Gavreto cleared in EU

pharmaphorum

ORR in patients previously treated with chemotherapy. billion in 2026 sales for Retevmo and $723 million for Gavreto, although that was before Roche lent its marketing muscle to the Blueprint drug. The median duration of response still hasn’t been reached for the treatment-naïve group in the ongoing trial, with a 22.3

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Trial win sets up new use for Astellas, Seagen’s Padcev in bladder cancer

pharmaphorum

Padcev (enfortumab vedotin) is already approved as a second-line therapy for urothelial carcinoma (UC) after cisplatin chemotherapy and immunotherapy with checkpoint inhibitors, but Seagen and Astellas are working towards earlier use of the drug. billion-a-year product in 2026, according to GlobalData.

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CHMP backs Roche’s lymphoma bispecific mosunetuzumab

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Analysts at Evaluate are predicting mosunetuzumab could make more than $500 million in sales in 2026, although other predictions go as high as $1 billion.

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Ibrance trial failure dashes Pfizer’s growth hopes for the drug

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The phase 3 PENELOPE-B trial was testing the CDK4/6 inhibitor as a potential treatment for early breast cancer patients who have residual invasive disease following neoadjuvant (pre-surgery) chemotherapy, but failed to show an improvement on the main measure of improved disease-free survival (iDFS).

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Future of Bispecific Antibody: Exploring the Rise in Approvals

Roots Analysis

One area of interest is in oncology , where bispecific antibodies can be used to target two different antigens at the same time, leading to improved efficacy and reduced toxicity compared to traditional chemotherapy. during the period 2023-2035.