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Sertraline: Everything you need to know about generic Zoloft

The Checkup by Singlecare

Zoloft is a brand-name medication with a generic option available called sertraline. Sertraline is the second most commonly prescribed antidepressant of 2023 so far (second to generic Lexapro), according to SingleCare script data. The primary difference between generic vs. brand-name drugs is the cost.