European Pharmaceutical Review

OCTOBER 9, 2022

Research published in the journal Nature Chemistry , shows how researchers from Stanford University in the US uncovered a promising new method to synthetically manufacture the compound tigilanol tiglate, named EBC-46, which could offer targeted medicine for cancer and other diseases.

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Compounding FDA 144

European Pharmaceutical Review

JANUARY 29, 2024

The guideline states that compounds “at or above the AET must be reported for toxicological risk assessment.” The researchers evaluated DHS extraction performance and compared it to traditional SHS and SBSE GC–MS methods. The paper highlighted that SHS analysis is currently a supplementary technique for volatile analysis.

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Compounding FDA 98

The Checkup by Singlecare

DECEMBER 18, 2023

Coffee itself doesn’t contain any cholesterol, but its natural oils contain kahweol and cafestol , two chemical compounds that have the potential to raise cholesterol levels. In other words, yes, the chemical compounds in coffee can raise cholesterol, but the effect coffee has on your cholesterol depends on individual factors.

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Compounding 105

Pharmaceutical Technology

NOVEMBER 29, 2022

This takeover will bolster the pipeline of Full-Life, offer a second peptide-based discovery platform and utilise the Radio Technology manufacturing and logistics platforms of Focus-X to progress compounds into clinics. The company’s pipeline currently has two lead compounds, which are set to enter clinical trials.

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Compounding 59

pharmaphorum

MARCH 7, 2022

The Princeton, New Jersey-based startup will use the funding to develop its artificial intelligence and imaging based drug discovery platform, used to identify compounds with new and under-exploited mechanisms of action.

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Compounding 137

The Checkup by Singlecare

AUGUST 15, 2024

Berries have compounds that can help lower blood sugar quickly,” he says. A 2020 study found that consuming cranberries, blueberries, raspberries, and strawberries can improve postprandial hyperglycemia and hyperinsulinemia (high insulin levels) in adults with insulin resistance who are overweight or obese.

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Compounding 98

European Pharmaceutical Review

OCTOBER 31, 2022

Solving this before the clinical stage ensures the viability of compounds…” Addressing bioavailability challenges in the first phases of development is essential to help create the most robust product profile and increase the potential for success as small molecule drugs move to the clinic. amorphous solid dispersions, or ASDs.

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Compounding Pharmaceutical Companies Pharmaceutical Companies FDA 125

The Checkup by Singlecare

APRIL 19, 2023

Garlic is loaded with organic sulfur compounds that make it particularly beneficial; these compounds fight inflammation, bacteria, fungi, and viruses, and have protective effects on the heart and kidneys. The garlic bulb (as part of the onion family alongside shallots , leeks , and chives) deserves a spot on this list—and your plate.

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Compounding Immunization 98

pharmaphorum

MARCH 24, 2022

GlaxoSmithKline has thrown its financial and drug development weight behind LifeMine Therapeutics, a US startup that aims to find new therapeutics from fungi – widely regarded as an underexplored resource of biologically-active compounds. Image by jggrz from Pixabay .

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Compounding Immunization 105

Pharmaceutical Technology

JULY 13, 2022

The initial agreement was signed in February 2020 for discovering, developing and marketing new immuno-oncology therapies based on Bicycle’s bicyclic peptide technology. The agreement is exclusive of the compounds in the oncology pipeline of Bicycle, including its immuno-oncology candidates.

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Compounding 59

Pharmaceutical Technology

FEBRUARY 6, 2023

In March 2020, the findings from the trial were published in the New England Journal of Medicine. We look forward to advancing this new compound as part of combination regimens that could yield a short, simple, safe, and highly effective cure for all forms of TB.”

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Compounding FDA 59

Pharmaceutical Technology

NOVEMBER 25, 2022

Additionally, the platform could produce preclinical tumour vaccine candidate compounds with strong immune activity by incorporating algorithmic feedback to streamline activity and efficacy. In September 2020, the company raised funds worth $318.8m Automated experiments will be used to monitor and validate the tumour vaccines.

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Vaccines Immunization Process Improvement Compounding 98

European Pharmaceutical Review

OCTOBER 7, 2022

billion by 2030, displaying a compound annual growth rate (CAGR) of 6.0 In the years 2015 and 2020, clinical-stage cancer programmes increased by a considerable 77 percent (1,642 to 2,911), resulting in a quarter of drugs currently in development worldwide being highly potent.

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Dosage Compounding Pharmaceutical Companies Pharmaceutical Companies 98

Pharmaceutical Technology

MAY 5, 2023

Since 2020, TFF Pharmaceuticals has entered into multiple CRADAs with various US government agencies that cover a broad range of applications, and today’s announcement with NIEHS is further recognition of thin film freezing’s potential.”

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Compounding 64

pharmaphorum

MARCH 19, 2021

In doing so it’s compounded pre-existing pressure with pharma, where schedules are shrinking and policies are often already restrictive enough to build barriers for effective physician engagement. The threat of disease spread and other risk factors from COVID-19 have only compounded this.

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Compounding Pharmaceutical Companies Pharmaceutical Companies Communication 141

Omnicell

SEPTEMBER 5, 2022

Mark Neuenschwander Founding Director, THRIVCoalition.org Seminal research from 1997 on IV compounding discovered that 9 percent of manually compounded sterile preparations had incorrect ingredients and/or volumes. Worst yet, 74% of all respondents were aware of at least one pharmacy compounding error in the last 12 months.

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Compounding Sterile Compounds Documentation Compounding Pharmacies 52

European Pharmaceutical Review

APRIL 8, 2024

stated that when conventional small-molecule compounds were the norm within the industry, closed innovation was standard practise and pharmaceutical companies did R&D in-house. noted that based on this analysis, approximately 20 percent of the total number of mAbs launched in 2020. Yoshiura et al. Yoshiura et al. Yoshiura et al.

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Pharmaceutical Companies Pharmaceutical Companies Compounding 52

pharmaphorum

MARCH 2, 2022

The term ‘psychedelic treatments’ incorporates a broad spectrum of different compounds, from LSD, psilocybin and DMT, to MDMA, ibogaine and ketamine. The latter compound has already been approved for treatment-resistance depression as the product Spravato (esketamine), after being developed by Janssen. Paving the way to patients.

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Compounding FDA 105

The People's Pharmacy

MAY 10, 2023

25, 2020 ). Researchers report benefit in conditions as varied as Barrett’s esophagus, multiple myeloma and prostate cancer ( Scientific Reports , March 17, 2020 ; American Journal of Hematology , March 6, 2020 ; Cancer Medicine , Feb. Many people take statin drugs to control their cholesterol.

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Chemotherapy Compounding Insurance 66

pharmaphorum

JUNE 30, 2022

AI-designed drug candidates are starting to reach the human testing stage, headed by Exscientia’s DSP-1181 candidate for obsessive-compulsive disorder partnered with Sumitomo Dainippon Pharma, which started a clinical trial in 2020.

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Research Laboratories Compounding 134

Pharmafile

JANUARY 5, 2023

Summary: • TMP-301 (formerly HTL0014242) is a potent, selective, and orally available mGluR5 negative allosteric modulator (NAM) candidate discovered by Sosei Heptares and out-licensed to Tempero Bio • Phase 1 study in healthy volunteers expected to begin in Q1 2023 with support from a US$5.3M

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FDA Compounding 40

pharmaphorum

JANUARY 11, 2023

The industry now hopes that feeding the same limited experiential data to AI may help tweak existing drug-like compounds slightly faster than before. Bucking the compound library trend, and the future. The drug candidates we find are vastly different from the compound libraries used by the rest of our industry.”.

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Compounding 122

pharmaphorum

JUNE 7, 2022

The Hong Kong-based startup – one of an emerging crop of companies which are using artificial intelligence platforms to discover and design new therapeutic compounds – took its first drug into clinical trials in February.

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Compounding 52

Hospital Pharmacy Europe

APRIL 5, 2023

Multiple sclerosis (MS) is the most common cause of neurological disability in young adults worldwide and a 2020 study estimated that, globally, some 2.8 million people are living with the condition. Although the underlying cause remains uncertain, there is evidence that certain dietary factors may have an effect.

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Compounding Hospitals 98

pharmaphorum

NOVEMBER 15, 2022

Their earlier partnership , signed in 2020, covered small molecule drugs directed at SLC transporters, a class of more than 450 human membrane proteins that are gatekeepers for controlling the movement of metabolites in and out of cells and organs.

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Immunization Compounding 105

pharmaphorum

JULY 13, 2022

Genentech has been looking at the platform since 2020 under the terms of a deal worth up to $1.7 Genentech has been looking at the platform since 2020 under the terms of a deal worth up to $1.7 The time the peptides stay in the body can also be fine-tuned, allowing for precise control of drug exposure, according to the biotech.

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Immunization Compounding 105

pharmaphorum

NOVEMBER 3, 2021

The report refers to data collected across 350+ global pharma companies between November 2020 through January 2021, and notes a 70% compound average growth rate in the volume of content managed in Veeva Vault PromoMats since 2018.

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Compounding Pharmaceutical Companies Pharmaceutical Companies Communication 98

pharmaphorum

MAY 12, 2022

These small drug compounds destabilise proteins by bringing them into proximity with enzymes called E3 ubiquitin ligases that cause them to be broken down. Compounds that modulate the activity of these enzymes have potential in oncology, for example, in blood cancers like multiple myeloma. billion partnership last week.

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Compounding 52

pharmaphorum

JANUARY 23, 2023

Morphic said it had received notice that Janssen had decided to pull out of the agreement, which initially focused on two targets but was revised at the end of 2020 to with the additional programme covering “antibody activators for an undisclosed integrin target.” In a filing with the Securities and Exchange Commission (SEC).

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Compounding FDA 52

pharmaphorum

OCTOBER 31, 2022

. “We are proud to be not just one of the few AI-driven biotech companies to have made it to the clinical stage, but also one of the first to bring forward a novel clinical compound against a novel target, that was entirely discovered and developed internally on our platform,” said Zhang, who acts as Verge’s chief executive.

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Compounding 136

pharmaphorum

JUNE 7, 2022

In a deal signed in 2020, the biotech bought a licence to co-develop and co-market inhibitors of LRRK2 – another target linked to lysosome function – from Denali Therapeutics. It’s not the first time that Biogen has licensed rights to a drug targeting lysosomal function in Parkinson’s disease.

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Compounding 80

pharmaphorum

FEBRUARY 2, 2022

ViiV claimed the latter compound infringes its patents for dolutegravir and other compounds based on the drug’s chemical scaffold. Gilead acquired the drug as part of its $21 billion takeover of Immunomedics in 2020. Gilead now expects product sales in 2022 will be between $23.8 billion and $24.3

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Compounding FDA 72

pharmaphorum

FEBRUARY 10, 2022

But the goals of maintaining that momentum and reaping the rewards of 21 st century processes rely on the sector attracting and retaining the staff – a proposition that’s becoming increasingly difficult thanks to a stubborn digital skills gap that is being compounded by the COVID brain drain. Digital skills gap. COVID brain drain.

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Compounding 105

pharmaphorum

AUGUST 24, 2020

SMi Reports: SMi Group have made the decision due to travel restrictions to open the conference and workshops to all microbiologists by transforming it into a virtual-remote online access event only on October 28 and 29 2020. SMi’s 3rd Annual Pharmaceutical Microbiology East Coast 2020. Conference: October 28th-29th, 2020.

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Compounding FDA Immunization 52

pharmaphorum

JUNE 27, 2022

Tazverik is a first-in-class EZH2a inhibitor that was cleared by the FDA in 2020 as a third-line or later treatment for adults with relapsed or refractory follicular lymphoma (FL) whose tumours have an EZH2 mutation. ” Epizyme’s shares are currently trading at around $0.95, well short of the stock’s 52-week high of $9.86.

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Compounding FDA 110

Hospital Pharmacy Europe

JUNE 27, 2024

Preparation is key According to the CGCPT, if nirmatrelvir plus ritonavir or molnupiravir ’had been available at scale in July 2020, in line with Covid-19 vaccine approval, it could have prevented millions of deaths globally’. Almost all the other targets described in Table 1 are enzymes important for functional viruses.

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Vaccines Compounding Immunization Hospitals 52

Hospital Pharmacy Europe

JUNE 27, 2024

Preparation is key According to the CGCPT, if nirmatrelvir plus ritonavir or molnupiravir ’had been available at scale in July 2020, in line with Covid-19 vaccine approval, it could have prevented millions of deaths globally’. Almost all the other targets described in Table 1 are enzymes important for functional viruses.

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Vaccines Compounding Immunization Hospitals 52