European Pharmaceutical Review

MAY 17, 2023

The viral therapy “aims to awaken the patient’s immune system and trigger a healing from within,” Dr Fueyo commented. After injection, patients that respond well develop inflammation inside the tumour, triggering an immune response that first kills the virus.” This makes it difficult to treat the cancer with immunotherapy.

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European Pharmaceutical Review

DECEMBER 12, 2023

He discusses why NK cell therapy’s ability to generate ‘synthetic immunity’ in the body means this modality holds potential as an anti-cancer treatment. We specialise in the development of new cutting-edge immunotherapies , based on the use of therapeutic antibodies capable of activating the immune system to fight cancer.

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pharmaphorum

AUGUST 5, 2022

MiroBio was formed in 2019 to develop checkpoint agonist antibodies for autoimmune and inflammatory disorders that can be used to apply the “natural brakes” of the immune system. 7 integrin, with three candidates in early-stage clinical development.

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Immunization 105

Hospital Pharmacy Europe

OCTOBER 2, 2024

The goal for cancer vaccines is straightforward: to harness what has been achieved for infectious diseases and their antigens to focus the immune system on eradicating cancer cells. Moving forward, exploring the factors contributing to variability in patients’ immune responses will be critical.

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European Pharmaceutical Review

JULY 13, 2023

The field of immunotherapy is constantly evolving with the ultimate goal to develop new treatments that help the body’s immune system fight cancer. Immune cells, such as T cells and natural killer (NK) cells, have the inherent ability to combat diseases, including cancer, but are often inhibited by the body’s own suppressive mechanisms.

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Pharmaceutical Technology

APRIL 12, 2023

The latest shipment is based on an exclusive licence agreement signed in 2019 between Pharming and Novartis. Both genes are important for the body’s development and for the functioning of immune cells. Under its terms, Pharming has paid a $10m milestone payment to Novartis for the first commercial sale of Joenja.

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Immunization FDA 59

European Pharmaceutical Review

JANUARY 26, 2024

It is a key component of human vaccines for shingles, malaria, coronavirus disease 2019 and others under development.” Bioengineering vaccine adjuvants The paper explained: “QS-21 is a potent vaccine adjuvant currently sourced by extraction from the Chilean soapbark tree. Martin et al. Martin et al.

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European Pharmaceutical Review

NOVEMBER 18, 2022

This is almost three times the 2019 market volume (5.8 billion), nearly three-and-a-half times the 2019 market value ($38 billion). Achieving Immunization Agenda 2030 goals. The document showed that in 2021, approximately 16 billion vaccine doses, worth $141 billion, were supplied across 47 vaccines and 94 manufacturers.

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pharmaphorum

JANUARY 10, 2023

Since then, the two partners have developed multiple AI-based applications including a platform for selecting neoantigens for use in individualised cancer vaccines and an early warning system for high risk SARS-CoV-2 variants based on how well they can evade the immune system and their transmissibility.

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Immunization Vaccines 116

Roots Analysis

FEBRUARY 28, 2024

On 28 October 2019, CARsgen Therapeutics , a clinical-stage biopharma company, announced that the FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to its investigational CT053 CAR-T cell therapy.

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Immunization FDA 52

pharmaphorum

JUNE 16, 2022

The result isn’t a big surprise – Roche terminated two phase 3 trials of crenezumab in people with prodromal to mild sporadic Alzheimer’s in early 2019 after interim analyses found it would be futile to continue – but is another blow to the amyloid hypothesis.

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Immunization 111

Druggist

AUGUST 8, 2020

Cell- or recombinant-based Vaccines an A/Hawaii/70/2019 (H1N1)pdm09-like virus; an A/Hong Kong/45/2019 (H3N2)-like virus; a B/Washington/02/2019 (B/Victoria lineage)-like virus; and a B/Phuket/3073/2013 (B/Yamagata lineage)-like virus. Flu season 2019/2020 ended on 31/03/2020. When did flu season end 2020?

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Vaccines Community Pharmacies Immunization Nursing Homes 98

Pharmaceutical Technology

MAY 25, 2023

The results from a trial, published in The New England Journal of Medicine , found the vaccine was associated with a strong immune response and good safety profile. The response was more powerful than that generated by MenACWY-D – a licensed quadrivalent meningococcal vaccine marketed by GSK.

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pharmaphorum

JUNE 15, 2022

Cytokines have long been investigated for their potential as cancer treatments – selectively stimulate tumour-fighting immune cells – with varying levels of success. The company came to Boehringer’s attention in 2019, when it took part in the drugmaker’s BI Innovation Prize competition.

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Immunization Vaccines 98

pharmaphorum

JANUARY 18, 2021

Quadri, formerly Merck’s head of medical and scientific affairs, immune oncology, has been charged with one count of theft of trade secrets and one count of unauthorised transmission of trade secrets, some relating to the multi-billion dollar cancer immunotherapy Keytruda (pembrolizumab).

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European Pharmaceutical Review

JULY 12, 2022

By binding to both CD19, an antigen expressed on B-cells, and to the CD3 receptor on T-cells, TNB-486 activates and recruits T-cells to CD19-expressing tumours where they can elicit an immune response. “By The post AstraZeneca to acquire TeneoTwo and its blood-cancer therapeutic appeared first on European Pharmaceutical Review.

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pharmaphorum

JULY 6, 2021

While these types of tests are important, they don’t tell the whole story, as they can’t provide information on whether an individual has built an immune response to COVID-19, either through vaccination or through a previous infection. This is where antibody tests come in. ” . . The Importance of Antibody Certificates.

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Immunization Vaccines 111

European Pharmaceutical Review

APRIL 25, 2023

This signals the cell to the immune system and so it targets and kills the myeloma cell. A promising treatment for myeloma DVD was first rolled out in 2019 after it was approved through the Cancer Drugs Fund.

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Immunization 98

Druggist

AUGUST 8, 2020

The prices for private flu jabs 2020/2021 service are as follows: Pharmacy chain Flu season 2020/2021 Flu season 2019/2020 Tesco Pharmacy £9 £9 Boots Pharmacy £13.99 £12.99 Flu season 2019/2020 ended on 31/03/2020. Available at: [link] Accessed on 07/08/2020 NHS England (2019). Asda Pharmacy £8 £7 Lloyds Pharmacy £12.99 £11.50

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Pharmaceutical Technology

SEPTEMBER 21, 2022

In January 2019, the companies entered a collaboration agreement under which Pfizer agreed to use CytoReason’s technology for developing cell-based models of the immune system. With the latest development, the partnership would be worth up to $110m over the next five years.

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Immunization 52

European Pharmaceutical Review

SEPTEMBER 22, 2023

The vaccination of patients with AN1792 led to the activation of their immune systems, which started producing endogenous anti-Abeta antibodies. Therefore, active immunotherapy to trigger the immune system to produce sustained levels of endogenous antibodies has now become far more attractive.

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pharmaphorum

JUNE 3, 2021

Genmab has enlisted the help of Bolt Biotherapeutics to develop a new class of immune-boosting antibody conjugates for cancer in a deal that could be worth up to $880 million. “Creating bispecific ISACs turbo-charged with potent immune stimulants is a novel concept that has tremendous potential for patients,” he added.

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Immunization 52

pharmaphorum

APRIL 28, 2021

Between just February and May 2020, submissions to Elsevier’s journals alone went up by 58% compared to the same period in 2019. “Text mining was also able to highlight new insights into the mechanisms of pancreatic cancer’s immune evasion, which refers to cancer cells’ ability to evade an immune response” .

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Immunization 105

pharmaphorum

JANUARY 20, 2021

Sweden’s Sobi has secured EU approval for Doptelet in primary chronic immune thrombocytopenia (ITP), an indication that the company expects to accelerate sales of the drug. Sobi acquired Doptelet via its $915 million takeover of Dova Pharmaceuticals in 2019, adding to its haematology and rare disease franchise.

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pharmaphorum

APRIL 8, 2022

Once within the tumour, it stimulates receptors on immune cells to mount an attack on the cancer. It was launched as Intron A by Schering-Plough (now Merck & Co) in the 1980s before being discontinued by the company in 2019 based on evaluation of its clinical activity and the emergence of alternative therapies.

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Immunization 105

pharmaphorum

MARCH 11, 2021

VX-880 (formerly known as STx-02) derives from Vertex’ near $1 billion acquisition of Semma in 2019, and has started enrolling patients in a phase 1/2 study in the US. As this won’t be used in the initial phase 1/2 trial, patients will have to receive immunosuppressive drugs to dampen down the immune response.

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pharmaphorum

MARCH 9, 2021

SARS-CoV-2 is likely to stay endemic in the human population for the foreseeable future, ExeVir noted, with variants capable of evading immunity the most likely cause of the disease in the future as global vaccination programmes begin to take effect. Ablynx, which is now a subsidiary of Sanofi following a $4.8

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Immunization Vaccines FDA 98

pharmaphorum

MARCH 4, 2022

settlement deal proffered last year by the family in return for immunity from current and future civil lawsuits accusing them of contributing to the opioid epidemic. The US saw nearly half a million deaths from overdoses between 1999 and 2019, according to the US Centers for Disease Control and Prevention (CDC).

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Immunization 98

pharmaphorum

AUGUST 31, 2022

Kaiku’s DPPM platform has also attracted the attention of other big pharma groups, including Roche which has been working with the company since 2019 on personalised support modules for patients taking its PD-L1 inhibitor Tecentriq (atezolizumab).

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The Checkup by Singlecare

DECEMBER 12, 2023

A compromised immune system can also contribute to fungal infections. This is due to several factors, such as having high blood sugar levels as well as the effects of diabetes on the immune system. This type of infection may be triggered by a warm, moist environment, which is conducive to fungal growth.

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Immunization 105

pharmaphorum

JANUARY 3, 2023

The most prominent of such therapies are immune checkpoint inhibitors, such as the PD-1/PD-L1 therapies that have become some of the best-selling treatments across the industry. What did change was the use of chemotherapy (26% in 2015 and 16% in 2019), and the increase in the delivery of immunotherapy (5% in 2015 and 18% in 2019).

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Chemotherapy Immunization Hospitals 105

pharmaphorum

FEBRUARY 3, 2021

The emergence of novel base editing technologies that do not generate double-strand breaks (DSBs) offer a promising and safer alternative to fine-tune the next generation of immune cell therapies, especially as our need to perform complex multi-gene alterations increases. Another area for potential improvement is the source of immune cells.

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Immunization Vaccines 98

Pharmaceutical Technology

FEBRUARY 26, 2023

EDP-1815 overview EDP-1815 is under development for the treatment of rheumatoid arthritis, skin inflammation, psoriasis, atopic dermatitis, and coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The therapeutic candidate is administered through oral route as a capsule.

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Immunization 40

pharmaphorum

SEPTEMBER 22, 2022

When exposed to a virus, one’s immune system develops antibodies in response to foreign antigens, with or without a vaccine. However, a vaccine trains the immune system to recognise that familiar virus and kill it more rapidly. Osivax’s technology, oligoDOM, trains the T-cell immune response to recognise the nucleoprotein.

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Vaccines Immunization 97

European Pharmaceutical Review

NOVEMBER 1, 2023

Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis. The current state of immunization against Gram-negative bacteria in children: a review of the literature. 2019 Jan; 7(1): e58-e67. 2019 Oct 16;7(4):151. 2022 [cited May2023], Available from: [link] Murray CJ, Ikuta KS, Sharara F, et al.

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pharmaphorum

JUNE 21, 2021

It would be easy to forget that back in 2019, BioNTech was an early-stage biotech firmly focused on cancer vaccines, before being catapulted onto the world-stage with its COVID-19 shot.

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pharmaphorum

OCTOBER 19, 2022

Patients across the UK with chronic immune thrombocytopenia (ITP) now have another treatment option, after NICE backed use of Spanish drugmaker Grifols’ Tavlesse for adults with the rare blood disorder. It has also been made commercially available in France, Italy, Spain, Norway and the Czech Republic, as well as Turkey.

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