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It is known as an antineoplastic (chemotherapy) agent, a disease-modifying antirheumatic drug ( DMARD ), and an immunosuppressant agent. Methotrexate has distinct mechanisms of action for its use as chemotherapy versus immunosuppression in autoimmune diseases.
While it can be used to manage many mental health conditions, including bipolar disorder and schizophrenia , it also plays a role in the prevention and treatment of chemotherapy-induced nausea and vomiting.
Chemotherapy agents: Chemotherapy agents can lead to constipation in a variety of ways such as slowing the movements of the intestinal tract or creating inflammation that disrupts digestive function. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; November 17, 2014. [29] Published 2014 Feb 28.
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