Pharmaceutical Technology

JULY 5, 2022

The team also found that the oral compound, RG7834, developed by Hoffmann-La Roche, hindered replication at a crucial step, preventing the virus from infecting liver cells. In addition, the research indicates that the compound was safe at the dosage level used in this research and the acute timeframe of the study.

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The FDA Law Blog

JULY 5, 2023

As a reminder, in Title I of the 2013 Drug Quality and Security Act (DQSA) (the Compounding Quality Act), Congress created the “outsourcing facility” FDA registration category, and set forth statutory parameters for their operation in new section 503B of the FDCA. 353b(a)(8). 353b(a)(8). Draft Guidance III.B.2(e) Draft Guidance III.B.2(d)

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Blog: Ask a Student Pharmacist

JUNE 21, 2023

Open Chained OR Fused 1, 1 '-Alkylene-Bis-Uracil Derivatives, Useful in Skin UV-Protection, US 2015 231051 A1 Vince, R, Raza, A and Dreis C.Sunless Tanning Compounds and Compositions, WO 2015 003095A1 Vince, R, Raza, A and Dreis C. 2013, 23(3), 620-3. Agents that Prevent or Repair Skin Damage, PCT Appl. Vince, R.

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Compounding 52

European Pharmaceutical Review

SEPTEMBER 25, 2023

NMR relaxation methods distinguish between components (phases or compounds) that have different molecular mobilities For monoclonal antibodies, identification methodologies can employ chromatography, spectroscopy, isoelectric focusing, capillary electrophoresis and peptide mapping techniques. 2013; 102(1): 52–61. J Pharm Sci.

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The Checkup by Singlecare

JANUARY 31, 2024

In fact, research links the compound to a reduced risk of age-related macular degeneration (AMD) and cataracts. Chan School of Public Health (2023) Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health , Nutrients (2013) Beta-carotene , Mt. RELATED: The 9 best foods for anemia 9. RELATED: Eye health 101 10.

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The Checkup by Singlecare

OCTOBER 26, 2023

Scientific studies have confirmed that thymoquinone, a compound found in black seed oil, is packed with antioxidants , along with antimicrobial, anti-inflammatory, and anti-cancer activity. However, thymoquinone , the active compound in the black cumin seed, has been shown to reduce the growth of certain cancer cells.

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The People's Pharmacy

APRIL 24, 2023

Some of the compounds found in this plant can trigger photosensitivity. This compound can damage both the lens and retina when the eye is exposed to light ( Photochemistry and Photobiology , Nov-Dec, 2012 ). Some scientists became concerned, however, about an under-appreciated side effect of St. John’s wort. John’s Wort?

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Compounding 63

The Checkup by Singlecare

FEBRUARY 8, 2024

Spices There’s a dual benefit to seasoning your food with certain spices—they add a depth of flavor and compounds that are beneficial for eczema. It’s a known anti-inflammatory agent, primarily due to the compound curcumin. Of them, turmeric is commonly recommended to soothe eczema.

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The People's Pharmacy

APRIL 10, 2023

An article published in Arthritis Research & Therapy (July 24, 2013) reports: “More than 30 million people use NSAIDs every day, and they account for 60% of the US over-the-counter analgesic market.” Surely pharmaceutical researchers should be able to develop newer and safer compounds. The numbers are astounding! Really common!

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The Checkup by Singlecare

DECEMBER 1, 2023

Grapefruit and grapefruit juice Grapefruit is known to interact with dozens of prescription medications , and Dr. Braunstein says Ozempic is no exception: “Grapefruit compounds can block the enzymatic breakdown of Ozempic and lead to higher levels of the drug [in the bloodstream] and increased side effects.”

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The Happy PharmD

OCTOBER 28, 2024

A significant data breach in 2013 compromised the credit and debit card information of millions, shaking consumer trust. Target’s overall profit margins were low, compounded by costly operational issues and the aftermath of shutting down its Canadian operations, which resulted in a $2.5 billion loss.

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The Checkup by Singlecare

FEBRUARY 19, 2024

A study published in 2013 found that people with chronic indigestion who took a product made of concentrated papaya pulp for 40 days saw improvement in gastrointestinal symptoms such as constipation and bloating. Fennel contains compounds that help relax the muscles in your digestive tract. This helps reduce gas and bloating.

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ISPE

MARCH 8, 2023

5 , 8 Compounding pharmacies were commonly mentioned as sources of microbial cross-contamination, especially in the US. 9 , 15 This has led to compounding pharmacies completing high-volume activities such as mass repackaging, thereby increasing the risk of cross-contamination. 17 (2013): 1598–1609. 3 (2013): 253–257.

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PharmD Live

MAY 30, 2024

The side effects can compound, resulting in a greater negative impact on a patient’s health than the individual effects of one medication alone. US Emergency Department Visits for Outpatient Adverse Drug Events, 2013-2014. Adverse Drug Reactions (ADRs) Adverse drug reactions are a major concern in polypharmacy. Neurology (2015).

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The Checkup by Singlecare

SEPTEMBER 28, 2023

Supplement with turmeric Curcumin is the main compound of the herb turmeric, and according to Dr. Garcia-Ibáñez, it works as a powerful antioxidant and anti-inflammatory. Garlic Garlic does contain anti-inflammatory compounds that, in theory, might reduce congestion. Controlled Clinical Trial (2013) Vitamin C. Harvard T.H.

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pharmaphorum

FEBRUARY 12, 2021

This may be compounded by a misconception that the field is mature, with the first discoveries having been made in the 1970s. The company was acquired by Ipsen in July 2013 where John became Head of Discovery for Ipsen Neurosciences and Site Head for the Ipsen Research facility near Oxford. It’s also extremely complex.

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Compounding 105

pharmaphorum

FEBRUARY 18, 2021

Eli Lilly’s Humalog compound and formulation patents expired in 2013 and 2014, respectively. 6 The stakes were extremely high, with annual costs of insulin reaching $736 per patient in 2013, up threefold since 2002. In late 2017, the FDA approved Admelog, Sanofi’s biosimilar of Humalog.

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The Checkup by Singlecare

FEBRUARY 2, 2024

To reduce inflammation : Various studies have shown that chlorophyll, chlorophyll derivatives, and chlorophyll-related compounds seem to have a positive effect in reducing inflammation and swelling. These anti-inflammatory properties could be useful in treating inflammatory conditions, such as arthritis.

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The People's Pharmacy

APRIL 24, 2023

A randomized controlled trial found that NAC was more effective than placebo in helping youngsters stop biting their nails ( Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry , 2013 ). After going through cancer treatment, she began taking this compound to support her liver. The study was small, however.

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Compounding 57

European Pharmaceutical Review

FEBRUARY 28, 2023

Pathways for N-Nitroso Compound Formation: Secondary Amines and Beyond. 2022; 35(11): 1997–2013. 1,2 Of the limited number of N -nitrosamines in the Lhasa Cancer Potency Database (LCPD), less than four percent are NDSRIs. EMA/409815/2020 Rev.13. López-Rodríguez R, McManus JA, Murphy NS, et al. Org Proc Res Dev. 2020; 24(9): 1558–1585.

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European Pharmaceutical Review

JANUARY 16, 2023

MALDI-TOF works on the basis of the ionisation of chemical compounds and measurements of their mass to charge (m/z) ratio. Prior to November 2013 he worked for Merck Research Laboratories in Summit, New Jersey as the Senior Principal Scientist in early phase drug development.

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The People's Pharmacy

APRIL 17, 2023

Be cautious with red yeast rice, though: it contains compounds related to statins and may cause similar side effects. 22, 2013 ). A systematic review of 12 studies shows that it can lower cholesterol, triglycerides and LDL ( Critical Reviews in Food Science and Nutrition, 2020 ). How do Statins and Muscle Symptoms Impact Exercise?

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Compounding 73

The Thyroid Pharmacist

NOVEMBER 4, 2022

While the human body (via the liver and kidneys) can produce up to 4 g/day of inositol, it has been found that the overly processed, high glucose (and low fiber) Western diets that many people follow, only provide about 1 g/day of the compound. (7). doi:10.1155/2013/424163. 2013 Feb;17(4):537-40. Journal of Thyroid Research.

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Druggist

AUGUST 27, 2020

Although not available in any other form, Tyrothricin is a combination of two different antibiotic compounds – gramicidin and tyrocidine. Schachtel (2013). 2019) and significant reduction of pain (Aspley et al., MHRA quite rightly challenged the sale of Tyrozets, which contain Tyrothricin. References: Aspley S.,B. Schachtel, P.

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The Thyroid Pharmacist

DECEMBER 7, 2022

A few of the most common types of flame retardants include: Halogenated compounds (containing bromine and/or chlorine and known as polychlorinated biphenyls, polybrominated diphenyl ethers, etc.). The PBDEs consisted of several commercial mixtures known as octa-BDE, penta-BDE, and deca-BDE (all phased out by 2013 in the U.S.;

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The Checkup by Singlecare

SEPTEMBER 22, 2023

The negative outcomes for BIPOC patients are compounded by the (understandable) anxiety about and distrust for the healthcare system and its providers. Medical Care Research and Review (2013) Racial and Ethnic Disparities in Health Insurance Coverage: Dynamics of Gaining and Losing Coverage over the Life-Course.

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The Checkup by Singlecare

NOVEMBER 9, 2023

These natural compounds help prevent oxidative stress—an excess of free radicals in the body that can cause cellular damage and systemic inflammation. These anti-inflammatory, anti-oxidative compounds are also found in foods like grapefruit, oranges, limes, and ginger. Of course, flavonoids don’t only exist in lemon water.

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The Spirit Pharmacist

FEBRUARY 21, 2023

Beyond lack of safety data, medical approval, and regulation as illicit substances, psychedelics are powerful serotonergic compounds that have pleiotropic effects across immune, endocrine, and neural systems. J Psychoactive Drugs, 2013. Psychedelics could also have considerable risks. Neuropsychopharmacology, 2022. dos Santos, R.G.,

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Pharmaceutical Technology

OCTOBER 25, 2022

From 1990 through 2013, the FDA approved 131 FDC products, on average 5.7 Recognising that cost savings, lower risk, and accelerated timelines can be achieved by partnering with a CDMO that has a proven track record of successfully producing FDC products is an important next step. More FDC products flowing into pharma pipelines.

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The Checkup by Singlecare

DECEMBER 6, 2023

When taken with other drugs that cause QT prolongation, this risk is compounded. QT prolongation may occur as a side effect of a medication or a drug interaction. Quetiapine may prolong the QT interval. Therefore, quetiapine typically isn’t prescribed with other drugs that cause QT prolongation.

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The Thyroid Pharmacist

AUGUST 18, 2023

Benefits and Uses of Curcumin Turmeric’s medicinal benefits can mostly be attributed to compounds called curcuminoids. Combining curcumin with piperine, an alkaloid found in black pepper, extends the life of curcumin in the body, making its compounds more therapeutically effective. Published 2013 Dec 6. 2013;2(4):636-652.

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The Thyroid Pharmacist

OCTOBER 28, 2022

Spore Flora contains five targeted Bacillus strains, which have the natural ability to produce a multitude of enzymes, secretory proteins (proteins secreted by cells), antimicrobial compounds, vitamins, and carotenoids (beneficial antioxidants). Published 2013 Apr 18. doi:10.1155/2013/767482. ScientificWorldJournal.

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The Thyroid Pharmacist

OCTOBER 21, 2022

In general, the anti-bacterial compounds derived from plant sources tend to spare the healthy gut bacteria more so than pharmacological antibiotics, which may decrease the risk of diarrhea and other digestive complications. doi:10.1155/2013/606212. Asian Pac J Trop Biomed. 2013;3(7):505-514. doi:10.1016/S2221-1691(13)60105-7.

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Blog: Ask a Student Pharmacist

JUNE 21, 2023

Jiashu Xie, PhD eomizowh Wed, 06/21/2023 - 10:11 Expand all + Biography Research Summary Current research in the Pharmacokinetics (PK) lab has focused on profiling the in vitro ADME (absorption, distribution, metabolism, and excretion) and in vivo PK properties of lead compounds from medicinal chemistry efforts.

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The Thyroid Pharmacist

SEPTEMBER 2, 2022

A 2013 study showed supplementation with myo-inositol and D-chiro-inositol led to a significant improvement in insulin sensitivity in those with PCOS. A study conducted in 2012-2013 showed a decrease in HBA1c (average blood sugar) levels in those who took 4000 IU of vitamin D daily, compared to the group that took a placebo. (53)

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The Thyroid Pharmacist

OCTOBER 25, 2022

Interestingly, these foods can also contain estrogen-mimicking compounds, which can contribute to estrogen dominance. A 2018 study found that a compound called zearalenone, an estrogen-like fungi, can colonize wheat, corn, and other grains. I first reached out to Magdalena in 2013, after publishing my book Hashimoto’s: The Root Cause.

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The Thyroid Pharmacist

DECEMBER 6, 2023

22] Nightshades contain alkaloids, which are chemical compounds that can be reactive substances in some people. Published 2013 Apr 18. doi:10.1155/2013/219840 [13] Eswaran S, Muir J, Chey WD. Forty-seven percent of readers found removing nightshades relieved their joint aches, pain, swelling, tingling, and numbness.

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