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It was at this time they set their site at Sandwich in the UK, initially just to finish processing compounds imported from America, but due to tariffs on imported products the company rapidly expanded the plant to accommodate producing medicines from scratch. Likewise, tanezumab, an anti-osteoarthritic, failed in trials.
6 , 13 , 14 The most commonly mentioned contaminants were Burkholderia species 5 , 8 as a whole, and vesivirus 2117 for Genzyme products in 2009. 5 , 8 Compounding pharmacies were commonly mentioned as sources of microbial cross-contamination, especially in the US. 11 Table 1: Contamination-associated recalls from 2017 to 2021.
During the Covid-19 pandemic, large-scale vaccine production placed unprecedented demand on the parenteral packaging industry. While production volumes have now fallen, future vaccine demand is hard to predict, as booster shots could be needed at any point to control emerging variants.
Since time immemorial, plants have been widely used as a source of medicinal compounds. However, upstream production in plants must also comply with additional laws relating to environmental release if grown outdoors (Directive 2001/ 18/EC, and 1829/2003/EC if the crop can be used as food/ feed) and Directive 2009/41EC if grown in constraint.
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