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The two groups were also separated by a sizeable time difference, with data from the control group ranging between 1990 and 2015, while Study 03-133 started enrolling patients in 2004. Changes in standard and supportive care over the time period could also have skewed the results, said the FDA reviewer.
A study in 2004 found an association between the presence of a mood or anxiety disorder, and the presence of anti-TPO antibodies. [1] In the early stages of Hashimoto’s, the thyroid is under attack by the immune system. Thyroid antibodies are a marker that lets us know that the immune system is destroying thyroid tissue.
TGF-β modulates inflammation and helps to induce and maintain the “tolerance of self” (which means the immune system is more capable of recognizing itself and less likely to attack itself), thus also reducing thyroid autoimmunity. LLLT also appears to increase Transforming Growth Factor β (TGF-β), which is an anti-inflammatory cytokine.
Both are tied to autoimmune processes in the body, when the immune system begins to recognize different parts of the thyroid gland as foreign invaders. A 2015 case report documented the thyroid labs of a man who had recurrent hyperthyroid episodes after three of his wife’s pregnancies! Published 2004 Aug 18. BMC Psychiatry.
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